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Research Journal of Pharmacognosy، جلد ۱، شماره ۳، صفحات ۲۷-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Cytotoxic activity of the essential oil of Salvia verticillata L.
چکیده انگلیسی مقاله Salvia is one of the largest genera of Lamiaceae family. Several species of this genus are perfumed and wealthy in essential oils. Some of them are used in industry, pharmacy and aromatherapy. They have shown different biological effects such as antibacterial and antioxidant activity. For the present study, Salvia verticillata L. was collected from Shahrestanak, Mazandaran, Iran. Hydrodistilled essential oil from the aerial parts of this plant was obtained with a Clevenger type apparatus and was analyzed by GC and GC/MS. Moreover, the cytotoxic activity of the essential oil was investigated against HT-29 (colon adenocarcinoma), Caco-2 (colorectal adenocarcinoma), T-47D (breast ductal carcinoma) and NIH-3T3 (Swiss mouse embryo fibroblast) cell lines by MTT test. 59 components were characterized from the oil with trans-caryophyllene (24.40%), β-phellandrene (9.08%), α-humulene (8.61%), bicyclogermacrene (6.32%), spathulenol (5.89%) and β-pinene (5.00%) as the major constituents. These compounds represented 97.67% of the essential oil and included monoterpenes (34.83%) and sesquiterpens (61.84%). The results of the cytotoxicity assay demonstrated that the essential oil of S. verticillata showed higher cytotoxic effect on Caco-2 cell line.
کلیدواژه‌های انگلیسی مقاله cytotoxic activity,Essential oil,MTT,Salvia verticillata
نویسندگان مقاله n خسروی دهقی | khosravi dehaghi
department of physiology and pharmacology, school of medicine, alborz university of medical sciences, karaj, iran.

سید نجم الدین استاد | s n
department of toxicology amp;amp; pharmacology and pharmaceutical sciences research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n معافی |
department of pharmacognosy, faculty of pharmacy and persian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s پدرام |
department of pharmacognosy, faculty of pharmacy and persian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

y اجنی |
institute of medicinal plants, acecr, karaj, iran
سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

a حاجی آخوندی |
department of pharmacognosy, faculty of pharmacy and persian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m خانوی |
3department of pharmacognosy, faculty of pharmacy and persian medicine and pharmacy research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_5775_57b33c5f440c03ea7ca26a0d3488d251.pdf
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