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Research Journal of Pharmacognosy، جلد ۱، شماره ۳، صفحات ۴۱-۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of some cosolvents and surfactants on viability of cancerous cell lines
چکیده انگلیسی مقاله Improving the solubility of non-soluble herbal materials is an issue of interest in cell culture based experiments. Evaluating the biological activity of these materials could become possible with the aid of cosolvents/surfactants which obviously should have little or no cytotoxic activity. In the present study, the cytotoxic activity of six cosolvents/surfactants: ethanol, methanol, Tween 20 and 80, propylene glycol (PG) and poly ethylene glycol 400 (PEG) which are usually helpful in dissolving non-soluble herbal extracts, has been evaluated against HepG-2, MCF-7 and HT-29 cells by MTT assay. Among the investigated cosolvents/surfactants, Tween 20 and 80 demonstrated the highest and ethanol and methanol the lowest cytotoxicity to the evaluated cell lines, suggesting the two latter as proper aids for improving solubility in biological experiments.
کلیدواژه‌های انگلیسی مقاله cell culture,Cosolvent,MTT assay,Solubility,Surfactant
نویسندگان مقاله m حمزه لو مقدم | hamzeloo moghadam
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran. department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

n طیبی |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran. pharmaceutical sciences branch, islamic azad university, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

m مصدق |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran. department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

b اسلامی تهرانی | eslami tehrani
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

s اسماعیلی |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran. department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_5777_9dc5c5256a5d2af01f9cf25200e897e9.pdf
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