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Research Journal of Pharmacognosy، جلد ۱، شماره ۲، صفحات ۲۳-۲۸
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عنوان انگلیسی Comparison of cytotoxic activity of some Iranian Stachys spp. extracts on different cancer cell lines
چکیده انگلیسی مقاله The genus Stachys belongs to Lamiaceae family with about 300 species and worldwide distribution. In the present study, the cytotoxic activity of four fractions of different Satchys species (S. byzatina C. Koch., S. inflata Benth., S. setifera Ten. and S. persica Gmel.), has been investigated against HT-29 (colon carcinoma), Caco-2 (colorectal adenocarcinoma), T-47D (breast ductal carcinoma) and NIH-3T3 (Swiss mouse embryo fibroblast) cell lines by MTT test. The samples were extracted by percolation method with four solvents; petroleum ether (60-80 ºC), chloroform, ethyl acetate and 80% aqueous methanol, susseccively. All cell lines were cultured in proper medium. Concentrations of 62.5-750 μg/mL from partition fractions of all samples, dissolved in 1% (v/v) DMSO were tested on each cell line. Cells with no treatment and methotrexate were examined as negative and positive controls, respectively. Cell viability was determined by MTT assay. Some fractions showed good cell inhibitory activity with IC50S. setifera was the most cytotoxic sample with high selectivity toward cancerous cell lines, and it could be investigated for its pharmaceutical active components in future studies.
کلیدواژه‌های انگلیسی مقاله cytotoxic activity,Lamiaceae,MTT assay,Stachys spp
نویسندگان مقاله سید نجم الدین استاد | s n
department of toxicology amp;amp; pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m وزیریان |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a منایی |
medicinal plants research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a حاجی آخوندی |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m خانوی |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran. department of traditional pharmacy, faculty of traditional medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_4755_2a2afc1a5bd6f3c89ded029a9bfb8807.pdf
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