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Research Journal of Pharmacognosy، جلد ۱، شماره ۲، صفحات ۲۹-۳۲
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عنوان انگلیسی Cytotoxic effects of selective species of Caryophyllaceae in Iran
چکیده انگلیسی مقاله Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells. There are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. Caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. The family is known for its ornamental plants and saponin compounds. In the present study, the potential cytotoxic activity of 17 selected species from Caryophyllaceae has been investigated against MCF-7, HepG-2, A-549, HT-29 and MDBK cells using MTT assay. Five species exhibited cytotoxic effects with IC50 values < 100 μg/mL. Silene ampullata and Acanthophyllum bracteatum extracts were toxic only against MCF-7 cell line suggesting them as suitable candidates for more investigations of breast cancer studies.
کلیدواژه‌های انگلیسی مقاله Caryophyllaceae,cytotoxic activity,MTT assay
نویسندگان مقاله f نقیبی |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran. department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

m ایرانی |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

a حسن پور |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

a پیرانی |
traditional medicine and materia medica research center, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

m حمزه لو مقدم | hamzeloo moghadam
department of traditional pharmacy, school of traditional medicine, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_4758_44aeedd35d408e5104b75da1e4e1977b.pdf
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