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Journal of Medical Microbiology and Infectious Diseases، جلد ۲، شماره ۴، صفحات ۱۳۳-۱۳۷
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عنوان انگلیسی Human Herpesvirus 6 Viremia in Patients with Classic Multiple Scelerosis in Guilan, Iran
چکیده انگلیسی مقاله Introduction: During the past few years, an increasing body of evidence has suggested a possible role for human herpes virus 6 (HHV-6) in Multiple Sclerosis (MS) pathogenesis. Despite the many reports supporting the relationship between HHV-6 and MS, this association has not been definitely proved or refuted, and the matter remains unresolved. The current study was aimed to investigate any relation between HHV-6 viremia and classic MS in patients in Guilan province, Northern Iran. Method: HHV-6 viremia was certified by molecular detection in study group (n=46) and control group (n=46) using nested-PCR. Data were analyzed by using three statistical tests (Chi square, odd ratio, and Relative Risk). Results: HHV-6 genomic sequences were found totally in 28 out of 46 (60.8%) plasma DNA samples of patients with MS, but were not found in rest of them. It was also found in 13 out of 46 (28.2%) control group. The difference in prevalence of HHV-6 DNA in blood between patients with MS and control group was statistically significant (P=0.0027 and odd ratio=0.277). Conclusion: The data of our study showed that HHV-6 can be implicated in the development of MS. We strongly support the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and MS.
کلیدواژه‌های انگلیسی مقاله Human Herpes virus 6, Multiple Sclerosis, Nested PCR, Iran
نویسندگان مقاله معصومه احمدی جلالی مقدم | masoumeh ahmadi jalali moghadam
cellular and molecular research center, faculty of medicin, guilan university of medical sciences, rasht, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

حمیدرضا هنرمند | hamidreza honarmand
p.o.box 44145-1533, lahijan,iran
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-76-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Infectious diseases and public health
نوع مقاله منتشر شده Original article
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