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Journal of Basic Research in Medical Sciences، جلد ۲، شماره ۳، صفحات ۱۷-۲۳
عنوان فارسی
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عنوان انگلیسی Down regulation of GTPase regulator associated with the focal adhesion kinase (GRAF) gene expression in patients with acute myeloblastic leukemia
چکیده انگلیسی مقاله Introduction: GTPase regulator associated with focal adhesion kinase (GRAF) is a recently identified GTPase activating protein that has the tumor suppressor properties. However, the expression level of GRAF in leukemia had received less attention. The main purpose of this research was the evaluating of the expression level of GRAF in patients with acute myeloid leukemia (AML). Materials and methods: Ninety people participated in the research (45 patients with AML and 45 healthy persons). RNA was extracted from their blood samples and cDNA synthesized. The expression levels of GRAF mRNA were determined by QRT-PCR method. Results: The expression levels of GRAF mRNA were significantly lower in AML samples than the control groups. WBC count was high in down-regulated samples than up-regulated ones (P< 0.05). There was any significant difference between two groups in other laboratories parameters. Conclusion: In spite of rare studies on GRAF gene expression level in patients with AML, was shown that it's down-regulated in people with AML.
کلیدواژه‌های انگلیسی مقاله Acute myeloblastic leukemia, GRAF
نویسندگان مقاله محمد هادی صادقیان | mohammad hadi sadeghian
department of hematology,faculty of paramedical sciences, ilam university of medical sciences, ilam, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)

محمد علیدادی | mohammad alidadi
4. department of physiology, faculty of medicine, ilam university of medical sciences, ilam, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)

حسین آیت اللهی | hossein ayatollahi
1. department of hematology and blood bank, cancer molecular pathology research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدرضا کرامتی | mohammad reza keramati
2. department of hematology, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عنایت انوری | enaiat anvari
1. department of hematology and blood bank, cancer molecular pathology research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسن بوستانی | hasan boustani
3. neonatal research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-99-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Immunology
نوع مقاله منتشر شده پژوهشی
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