این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Archives of Breast Cancer، جلد ۱، شماره ۳، صفحات ۸۶-۹۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Predictive Role of EGFR, IGF-1R, VEGFR2 and HIF-1α Expression on Survival of Patients with Triple-negative Breast Cancer
چکیده انگلیسی مقاله Background: Triple-negative breast cancer (TNBC) carries a poor prognosis and therapeutic options are limited to date. The aim of this study was to investigate to what extent the epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor 2 (VEGFR2), hypoxia inducible factor-1 alpha (HIF-1α) and insulin-like growth factor-1 receptor (IGF-1R) are expressed in TNBC and to determine if these expressions have a predictive role. Methods: Of 923 breast cancer patients who were treated and followed in Academic Center for Education, Culture and Research (ACECR) from 2006-2010, 104 of them had TNBC. Immunohistochemistry analyses were performed on tissue microarray blocks with antibodies for EGFR, VEGFR2, HIF-1α and IGF-1R. Results: We analyzed tumor samples from 104 patients with classic primary invasive ductal carcinoma (IDC). Fifteen patients (14%) were in stage I, 46.6% in stage II, 30.1% in stage III and 5.8% in a metastatic stage (stage IV). The median overall survival (OS) was 48 months. EGFR was expressed in 15 (14%), VEGFR2 in 63 (61%), IGF-1R in 81 (78%) and HIF-1α in 57 (55%) samples. EGFR expression was significantly associated with poor outcome in terms of OS (P = 0.021, OR = 3.9). Conclusions: Among the four investigated tumor markers, only EGFR was significantly associated with survival of patients with TNBC.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله صفا نجفی | safa najafi
breast diseases department, breast cancer research center, acecr, tehran, iran


رضا مهدی زاده | reza mehdizadeh
department of cell and molecular biology, college of biology, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

عیسی جهانزاد | eissa jahanzad
department of pathology, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آسیه الفت بخش | asiie olfatbakhsh
breast diseases department, breast cancer research center, acecr, tehran, iran


آرش جنابیان | arash jenabian
islamic azad university of tehran, medical branch, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

غلامرضا اسماعیلی جاوید | gholamreza esmaeeli javid
biostatistics and epidemiology committee, iranian center for medical lasers icml , acecr, tehran, iran


مسعود حبیبی | masoud habibi
breast diseases department, breast cancer research center, acecr, tehran, iran


ماندانا ابراهیمی | mandana ebrahimi
breast diseases department, breast cancer research center, acecr, tehran, iran
نشانی اینترنتی http://www.archbreastcancer.com/index.php/abc/article/view/19
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات