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Middle East Journal of Cancer، جلد ۱۰، شماره ۱، صفحات ۱-۰
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عنوان انگلیسی Chronic Psychosocial Stress in Relation to Cancer
چکیده انگلیسی مقاله Cross-sectional observational studies reveal that cancer is more prevalent in depressed persons. Psychosocial stressors such as depression, anxiety, stressful life events, poverty, and lack of social support may favor carcinogenesis. Cancer acquired under these circumstances has a poor prognosis. Conversely, when cancer has developed in the presence of these factors, effective management or treatment of these psychosocial stressors may bring about increased survival time of the affected persons. The purpose of this narrative literature review is to examine the role that maladaptive stress responses play in cancer initiation and progression. Relevant databases, hand searches and authorative texts were critically analysed and the findings were integrated. Stress is influenced by genetic, environmental, pharmacological, and infectious factors in addition to the chronicity of depression, social isolation, and poor stress-coping capacity. Chronic psychosocial stress-induced maladaptive activation of the neuroendocrine system may dysregulate immunoinflammatory responses, alter oncogene expression, promote tumor-related angiogenesis, and accelerate growth of cancer with stimulation of neuroendocrine activity, which may favor cancer progression. The evidence that associates psychosocial stressors to cancer progression is stronger than the evidence which links the same psychosocial stressors to cancer incidence.
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نویسندگان مقاله | Liviu Feller
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa


| Razia Abdool Gafaar Khammissa
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa


| Raoul Ballyram
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa


| Rakesh Chandran
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa


| Johan Lemmer


نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/838
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-1206789.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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