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Journal of Craniomaxillofacial Research، جلد ۳، شماره ۲، صفحات ۱۸۵-۱۹۰
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عنوان انگلیسی Association between the serotonin- transporter- linked polymorphic region (5-HTTLPR) and pemphigous disease in Iranian patients
چکیده انگلیسی مقاله Introduction : Pemphigus vulgaris (PV) is a relatively rare autoimmune disease characterized by blistering of the skin and mucosa. The main objective of this study was to investigate the possible association between the 5-HTTLPR polymorphism and PV in Iranian patients. For this, 112 PV and 100 controls were enrolled in this study. Materials and Methods : In this case-control study, Genomic DNA was extracted from whole blood and genotyping of all participants for the 5-HTTLPR polymorphism was carried out using the polymerase chain reaction (PCR) technique. The genotypes were grouped into three classes: homozygous for the short allele (SS), heterozygous for the short and long allele (LS) and homozygous for the long allele (LL). Results : Our results showed no significant association between the 5-HTTLPR polymorphism genotypes, LL, SS and LS in PV patients compared to controls. Also, our finding did not reveal any evidence of an association between this disease and the allele frequency of S and L. Taken together, our findings suggested that the 5-HTTLPR polymorphism is unlikely to be a factor contributing to the risk of developing pemphigus vulgaris. Conclusion : It can be concluded that although 5-HTTLPR polymorphism seems to be associated with some of auto-immune and stress-related disease. Key words : Iranian Population, PCR, Pemphigus vulgaris, Polymorphism, Risk Factor.
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نویسندگان مقاله شمس الملوک نجفی | shamsolmolok najafi
oral medicine department, dental school, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نفیسه اسماعیلی | nafiseh esmaili
skin amp;amp; hair department, razi hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منصور حیدری | mansour heidari
eye research center, farabi eye hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرحناز قاسمی | farahnaz ghassemi
craniomaxillofacial research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

میثم محمودی | meisam mahmoudi
dentist


مهسا محمدزاده | mahsa mohammadzadeh
dentist


عبدالرضا محمدنیا | abdolreza mohamadnia
virology research center, national research institute of tuberculosis and lung diseases nritld , shahid beheshti university of medical sciences, tehran, iran. biotechnology department, advanced technologies in medicine, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نغمه بهرامی | naghmeh bahrami
oral and maxillofacial surgery department, school of dentistry, tehran university of medical sciences, tehran, iran. craniomaxillofacial research center, tehran university of medical sciences,tehran,iran, iranian tissue bank amp;amp; research center, tehran university of medical sciences ,tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jcr.tums.ac.ir/index.php/jcr/article/view/75
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