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Journal of Craniomaxillofacial Research، جلد ۳، شماره ۱، صفحات ۱۵۷-۱۶۰
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عنوان انگلیسی Assessment of relation between antioxidants level and clinical manifestation in recurrent aphtous stomatitis
چکیده انگلیسی مقاله Introduction : Recurrent aphthous stomatitis (RAS) is a common disease with unknown etiology and no treatment. The purpose of this study is to assess the relationship between serum antioxidants level and clinical manifestation. Change in antioxidant level can lead inflammatory reaction through oxidative stress. Materials & Methods : A total 50 patients were selected for this cross sectional study. Superoxide dismutase (SOD), glutathione peroxidase (GSHPX) and total antioxidant status (TAS) was measured in plasma. Also pain intensity based on the visual analogue scale (VAS), the mean interval between lesion, number of lesions and the mean duration of complete healing were recorded. Statistical analysis was performed by using spearman, chi square and T-test. Results : We had 50 patients include 28 female and 22 male. Mean and standard deviation was for TAS (1.35±0.15), GPX (178.42±39.67) and SOD (257.86±63.17). Number of lesion and duration of RAS had direct relationship with pain severity. Pain intensity and GPX and SOD were significant (respectively 0.05, 0.04). GPX and SOD level was indirectly related (p=0.04). Conclusion : We could show that RAS patients had alteration in SOD and GPX level but TAS level was stable. Against TAS level which had no change, with more lesion and severe pain GPX level is lower and SOD level was higher. These two antioxidants were related indirectly. Key Words : Recurrent aphthous stomatitis, Antioxidants, Symptoms, Superoxide dismutase (SOD), glutathione peroxidase (GSHPX), total antioxidant status (TAS).
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نویسندگان مقاله shamsolmolouk نجفی | shamsolmolouk najafi
department of oral medicine, school of dentistry, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ارغوان تنکابنی | arghavan tonkaboni
department of oral medicine, school of dentistry, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهسا محمدزاده | mahsa mohammadzadeh
dentist
نشانی اینترنتی http://jcr.tums.ac.ir/index.php/jcr/article/view/70
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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