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Journal of Craniomaxillofacial Research، جلد ۳، شماره ۱، صفحات ۱۶۱-۱۶۵
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عنوان انگلیسی Salivary antioxidant levels in pemphigus vulgaris patients compared to the healthy people
چکیده انگلیسی مقاله Introduction : Pemphigus comprises a group of diseases characterized by cutaneous and mucosal blistering. Pemphigus vulgaris (PV) is the most common and important variant. Recent reports have revealed the relatively high incidence of PV in Iran. The onset or aggravation of many human diseases is attributed to oxidative stress and it has been suggested as one of the several factors responsible for etiopathogenesis of pemphigus. The present study sought to assess the association of salivary level of antioxidant enzyme glutathione peroxidase (GPx) and total antioxidant level with pemphigus vulgaris. Materials and Methods : This case-control study evaluated patients referred to Razi Dermatology Hospital in Tehran , Iran from January to November 2011. Thirty patients with early diagnosed PV, who had never been on treatment were enrolled in this study. The diagnosis of PV was confirmed by histopathology and direct immunofluorescence. The control group consisted of 30 age- and sex-matched healthy non-smoker volunteers. Saliva was collected from subjects for evaluation of glutathione peroxidase and total antioxidant levels and comparison with controls. GPX and TAS activity was analyzed by spectrophotometry . Independent samples t-test was applied to compare the means of continuous variables. Statistical analysis was performed using SPSS software. P ≤ 0.05 was considered significant. Results : The mean salivary level of glutathione peroxidase was significantly lower in pemphigus patients. No statistically significant difference was observed between the groups in total antioxidant levels of saliva. Conclusion : Our findings indicated that lower levels of glutathione peroxidase may be associated with pemphigus vulgaris. Salivary GPx level may be used for diagnosis of PV. Key words : Antioxidant, Pemphigus vulgaris, Glutathione peroxidase.
کلیدواژه‌های انگلیسی مقاله Antioxidant,Pemphigus vulgaris,Glutathione peroxidase.
نویسندگان مقاله شمس الملوک نجفی | shamsolmolok najafi
department of oral medicine and dental research center, campus international dentistry faculty, tehran university of medical sciences, tehran, iran. dental school, tehran university of medical sciences.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نغمه بهرامی | naghmeh bahrami
craniomaxillofacial research center, tehran university of medical sciences, tehran, iran. oral and maxillofacial surgery department, school of dentistry, tehran university of medical sciences, tehran, iran. iranian tissue bank amp;amp; research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نفیسه اسماعیلی | nafiseh esmaili
autoimmune bulbous diseases research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهسا محمدزاده | mahsa mohammadzadeh
dentist


نرگس قلی زاده | narges gholizade
department of oral medicine and dental research center, dental school, tehran university of medical sciences.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سودابه مهدوی | soudabeh mahdavi
dentist


عبدالرضا محمدنیا | abdolreza mohamadnia
virology research center, national research institute of tuberculosis and lung diseases nritld , shahid beheshti university of medical sciences, tehran, iran. biotechnology department, advanced technologies in medicine, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://jcr.tums.ac.ir/index.php/jcr/article/view/71
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