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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۱، صفحات ۷۴-۸۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds
چکیده انگلیسی مقاله Cancer is a major cause of death worldwide and novel anticancer agents for its better management are much needed. Benzopyrone-based compounds, such as chromones, possess several distinctive chemical and biological properties, of which the cytotoxicity against cancer cells seems to be prominent. In this study, two series of compounds based on chromen-4-one ( 3-10 ) and chromane-2,4-dione ( 11-18 ) scaffolds were synthesized in moderate/high yields and evaluated for cytotoxicity against HL-60, MOLT-4, and MCF-7 cancer cells using MTT assay. In general, the compounds exhibited moderate cytotoxic effects against the cancer cell lines, among which, a superior potency could be observed against MOLT-4 cells. Chroman-2,4-dione ( 11-18 ) derivatives had overall higher potencies compared to their chromen-4-one ( 3-10 ) counterparts. Compound 13 displayed the lowest IC 50 values against HL-60 (IC 50 , 42.0 ± 2.7 µM) and MOLT-4 cell lines (IC 50 , 24.4 ± 2.6 µM), while derivative 11 showed the highest activity against MCF-7 cells (IC 50 , 68.4 ± 3.9 µM). In conclusion, this study provides important information on the cytotoxic effects of chromone derivatives. Benzochroman-2,4-dione has been identified as a promising scaffold, which its potency can be modulated by tailored synthesis with the aim of finding novel and dissimilar anticancer compounds.
کلیدواژه‌های انگلیسی مقاله Antineoplastic agents,Cancer,Chromones,Drug screening.
نویسندگان مقاله | Alexandra Gaspar
2Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Maryam Mohabbati
1CIQUP/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.


| Fernando Cagide
3Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran. 4Drugs and Advanced Sciences Research Center, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.


| Nima Razzaghi-Asl
2Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Ramin Miri
2Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.


| Omidreza Firuzi
1CIQUP/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.


| Fernanda Borges


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1880
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1262573.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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