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International Journal of Organ Transplantation Medicine، جلد ۱۰، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Association of IL-12 and TNF-α Polymorphisms with Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients
چکیده انگلیسی مقاله Background: Cytokines are important factors determining the outcome of transplantation. The host ability in cytokine production may be affected by cytokine genes polymorphisms. Objective: To investigate the effect of IL-12 and TNF-α gene polymorphisms on outcome of hematopoietic stem cell transplantation. Methods: 90 bone marrow transplant recipients were included in this study. 30 (33%) of 90 recipients experienced graft-versus-host disease (GVHD). IL-12 and TNF-α gene polymorphisms were evaluated by PCR-RFLP and ARMS-PCR method, respectively. Results: No significant difference in the distribution of IL-12 (rs3212227 +1188 A/C) and TNF-α (rs 1800629 -308 G/A) genotypes and alleles was observed between those with and without GVHD. There was no significant association between the distribution of genotypes and the recipient sex. Conclusion: IL-12 (rs3212227 +1188 A/C) and TNF-α (rs 1800629-308 G/A) genotypes and alleles were not risk factors for development of GVHD.
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نویسندگان مقاله | M H Karimi
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| S Salek
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran and Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran


| R Yaghobi
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| M Ramzi
Hematology Research Center and Bone Marrow Transplant Unit, Shiraz University of Medical Sciences, Shiraz, Iran


| B Geramizadeh
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| F Kafilzadeh
Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran
نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/469
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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