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International Journal of Nanoscience and Nanotechnology (IJNN)، جلد ۱۱، شماره ۳، صفحات ۱۳۹-۱۴۶
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Study of Mesoporous Silica Nanoparticles as Nanocarriers for Sustained Release of Curcumin
چکیده انگلیسی مقاله Curcumin (CUR) is a hydrophobic molecule and beneficial antioxidant with known anticancer property. The bioavailability of curcumin is low because of its hydrophobic structure. Mesoporous silica nanoparticles (MSN) loaded by CUR were used as nanocarriers for sustained release of CUR in four different media such as simulated gastric,intestinal, colon and body fluids (SGF, SIF, SCF, and SBF, respectively). In this study MSN and its amine-functionalized (AP-MSN) were synthesized, loaded by CUR and then characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), N2 adsorption isotherms, X-ray diffraction (XRD) and thermal gravimetric analysis (TGA). TGA showed that the amount of CUR loaded into MSN and AP-MSN (named MSN-CUR, AP-MSN-CUR, respectively) was 1.44 and 9.5%, respectively. Entrapment efficiency of CUR in MSN and AP-MSN was found to be 3.6 and 23.75%, respectively. Release rate of CUR from AP-MSN-CUR was slower than that from MSN-CUR at different pHs of media. In addition, the release rate of CUR from AP-MSN-CUR in acidic buffer solution was slower than that in alkaline media.
کلیدواژه‌های انگلیسی مقاله Antioxidant,Curcumin,Mesoporous silica nanoparticles,release
نویسندگان مقاله a بلوکی |
chemical engineering department, islamic azad university shahrood branch, shahrood, i. r. iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

l رشیدی |
food and agriculture department, standard research institute, iranian national standards organization, i. r. iran

e واشقانی فراهانی | vasheghani farahani
biotechnology division, chemical engineering department, tarbiat modares university, tehran, i. r. iran.
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

z پیراوی ونک | piravi vanak
food and agriculture department, standard research institute, iranian national standards organization, i. r. iran

نشانی اینترنتی http://www.ijnnonline.net/article_14567_62eb20a54a86ca972b373fde4f8649b1.pdf
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