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The Archives of Bone and Joint Surgery، جلد ۷، شماره ۲، صفحات ۱۸۲-۱۹۰
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عنوان انگلیسی Histomorphometric Analysis of Newly-formed Bone Using Octacalcium Phosphate and Bone Matrix Gelatin in Rat Tibial Defects
چکیده انگلیسی مقاله Background: Repair of bone defects is challenging for reconstructive and orthopedic surgeons. In this study, we aimedto histomorphometrically assess new bone formation in tibial bone defects filled with octacalcium phosphate (OCP),bone matrix gelatin (BMG), and a combination of both.Methods: A total of 96 male Sprague Dawley rats aged 6-8 weeks weighing 120-150 g were randomly allocatedinto three experimental (OCP, BMG, and OCP/BMG) and one control group (n=24 in each group). The defects inexperimental groups were filled with OCP (6 mg), BMG (6 mg), or a combination of OCP and BMG (6 mg, 2:1 ratio).No material was used to fill the defects in the control group and the defect was only covered with Surgicel. Sampleswere taken on days 7, 14, 21, and 56 after the surgery. The sections were stained with hematoxylin-eosin (H&E) andassessed using light microscopy.Results: In our experimental groups, bone formation was started from the margins of the defect towards the centerwith an increasing rate during the study period. Moreover, the formed bone was more mature. Bone formation in ourcontrol group was only limited to the margins of the defect. The newly formed bone mass was significantly higher inthe experimental groups (P=0.001).Conclusion: OCP, BMG, and OCP/BMG compound enhanced osteoinduction in long bones.Level of evidence: III
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نویسندگان مقاله | Fereydoon Sargolzaei Aval
Cellular and Molecular Research Center & Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Mohamad R. Arab
Cellular and Molecular Research Center & Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Narjes Sargolzaei
Department of Community Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Sanam Barfroushan
Cellular and Molecular Research Center & Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Mohsen Mir
Cellular and Molecular Research Center & Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Gholam Hossein Sargazi
Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Forough Sargolzaei Aval
Department of Pathology, University of Washington, Seattle, Washington, USA


| Maryam Arab
Cellular and Molecular Research Center & Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
نشانی اینترنتی http://abjs.mums.ac.ir/article_10835.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/328/article-328-1285414.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده RESEARCH PAPER
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