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Iranian Journal of Biotechnology، جلد ۱۲، شماره ۳، صفحات ۱-۸
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عنوان انگلیسی Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe, natural and effective antibiotic inhibits the infection of Staphylococcus aureus and Pseudomonas aeruginosa in vivo
چکیده انگلیسی مقاله Background: Curcumin as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. One of the nanoparticles ability is to decrease the defects of usual drug delivery systems. Chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of nanoparticles. Nanoparticles like chitosan-tripolyphosphate (TPP) are able to increase antibacterial properties of curcumin. Materials and methods: Curcumin-loaded chitosan-TPP nanoparticles containing chitosan, curcumin and TPP salt were synthesized by ionotropic gelation methods. First, the skin of anesthetized mice was inoculated with staphylococcus aureus and pseudomonas aeruginosa suspension. Then the infected mice were treated with curcumin-loaded chitosan-TPP nanoparticles for 3 days. Following that, antibacterial characteristics of the mice treated with curcumin-loaded chitosan-TPP nanoparticles were evaluated by bacterial culture of these mice. Results: Our results showed the size of 160±10 nm and the charge of +7 ± 2 mV in curcumin-loaded chitosan-TPP nanoparticles. These nanoparticles were also spiral shape. The encapsulating efficiency of curcumin in chitosan-TPP nanoparticles was 75 ± 2%. Bacterial culture showed that curcumin-loaded chitosan-TPP nanoparticles inhibited staphylococcus aureus and pseudomonas aeruginosa growth. Conclusion: Our study demonstrated that curcumin-loaded chitosan-TPP nanoparticles can be utilized as a potent agent in treatment of Staphylococcus aureus and Pseudomonas aeruginosa infections.
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نویسندگان مقاله رضا میرنژاد |
molecular biology research center, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

میرزا علی مفضل جهرمی | mirza ali mofazzal jahromi
molecular biology research center, baqiyatallah university of medical sciences, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

سیدشرف الدین موسوی | al musawi
departments of nanobiotechnology, faculty of biological sciences, tarbiat modares university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مجید پیرستانی |
department of parasitology, faculty of medical sciences, tarbiat modares university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مهدی فصیحی رامندی | fasihi ramandi
molecular biology research center, baqiyatallah university of medical sciences, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

کاظم احمدی |
department of immunology and research centre of molecular biology, baqiyatallah university of medical sciences, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

هاجر رجایی |
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

زهیر محمد حسن | mohammad hassan
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مهدی کمالی |
nanobiotechnology research center, baqiyatallah university of medical sciences, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://www.ijbiotech.com/article_6452_9abc329feef64c9ff086d89231533567.pdf
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