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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۴، صفحات ۳۴۵-۳۵۲
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عنوان انگلیسی Scenario and future prospects of microRNAs in gastric cancer: A review
چکیده انگلیسی مقاله Carcinoma of the stomach is one of the major prevalent and principal causes of cancer-related deaths worldwide. Current advancement in technology has improved the understanding of the pathogenesis and pathology of gastric cancers (GC). But, high mortality rates, unfavorable prognosis and lack of clinical predictive biomarkers provide an impetus to investigate novel early diagnostic/prognostic markers and therapeutic targets for GC, which are sufficiently sensitive to GC. Current biomedical investigations have explored several budding GC biomarker by utilizing serum proteins, natural oncogenic genes during improvement in molecular technologies as microarray, and RNA/DNA-Seq. Recently, small non-coding microRNAs (miRNAs) are becoming vital regulators in oncogenesis pathways and can act as handy clinical biomarkers. The newly introduced class of biomarkers is rising as new molecules for cancer diagnosis and prognosis. For better understanding of the gastric carcinogenesis, miRNAs may help to elucidate the mechanisms of tumor growth and can help to discover novel untimely potent markers for early detection of GC. Here in this review, we summarize the recent research studies supporting the utility of miRNAs as novel early diagnostic/prognostic tools and therapeutic targets. Thus, here we introduce potential future treatment strategies for gastrointestinal (GI) cancers, which indicate the practicality and clinical applications of miRNAs in GC.
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نویسندگان مقاله | Showkat Ahmad Bhat
Department of Biochemistry, Govt. Medical College, Srinagar Jammu & Kashmir, India


| Sabhiya Majid
Department of Biochemistry, Govt. Medical College, Srinagar Jammu & Kashmir, India


| Muneeb U Rehman
Department of Biochemistry, Govt. Medical College, Srinagar Jammu & Kashmir, India
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12317.html
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کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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