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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۴، صفحات ۴۰۷-۴۱۱
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عنوان انگلیسی Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats
چکیده انگلیسی مقاله Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically.Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group.  On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues.
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نویسندگان مقاله | Evren Kose
Department of Anatomy, School of Medicine, Inonu University, Malatya, Turkey


| Fatih Oguz
Department of Urology, School of Medicine, Inonu University, Malatya, Turkey


| Nigar Vardi
Department of Histology-Embryology, School of Medicine, Inonu University, Malatya, Turkey


| Mehmet Sarihan
Department of Emergency, School of Medicine, Inonu University, Malatya, Turkey


| Ali Beytur
Department of Urology, School of Medicine, Inonu University, Malatya, Turkey


| Aytac yucel
Department of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey


| Alaadin Polat
Department of Physiology, School of Medicine, Inonu University, Malatya, Turkey


| Nihat Ekinci
Department of Anatomy, School of Medicine, Erciyes University, Kayseri, Turkey
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12288.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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