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Research Journal of Pharmacognosy، جلد ۶، شماره ۲، صفحات ۱-۷
عنوان فارسی Cytotoxic Activity of Juniperus excelsa M. Bieb. Leaves Essential Oil in Breast Cancer Cell Lines
چکیده فارسی مقاله Background and objectives: Juniperus excelsa is a flowering plant that has been applied as traditional medicine for treatment of various disorderssuch asdysmenorrhea, bronchitis and colds, jaundice and tuberculosis. The aims of the present study were analyzing J. excelsa essential oil and investigation of its cytotoxic activityon three breast cancer cell lines.  Methods:  Juniperus excelsa leaves were collected from Dena mountains, located in the south-west of Iran. The composition of the essential oil of was analyzed by gas chromatography-mass spectrometry (GC/MS). Cytotoxic activity was evaluated using MTT assay.   Results: Forty-one components, related to 99.83% of the total oil, were identified. Monoterpene hydrocarbons represented the major components of the volatile oil while α-pinene (73.27%) was the major component. The essential oil showed significant cytotoxic activity against breast cancer cell lines MCF-7 (IC50=0.084 µg/mL), MDA-MB-231 (IC50=0.090 µg/mL) and T-47D (IC50=0.124 µg/mL).  Conclusion: The analysis of J. excelsa oil revealed α-pinene and cedrol as the main compounds of the volatile oil that could justifiy its remarkable cytotoxic effect against the tested cell lines.
کلیدواژه‌های فارسی مقاله Cytotoxic،، Juniperus excelsa،، MTT assay،
عنوان انگلیسی Cytotoxic Activity of Juniperus excelsa M. Bieb. Leaves Essential Oil in Breast Cancer Cell Lines
چکیده انگلیسی مقاله Background and objectives: Juniperus excelsa is a flowering plant that has been applied as traditional medicine for treatment of various disorderssuch asdysmenorrhea, bronchitis and colds, jaundice and tuberculosis. The aims of the present study were analyzing J. excelsa essential oil and investigation of its cytotoxic activityon three breast cancer cell lines.  Methods:  Juniperus excelsa leaves were collected from Dena mountains, located in the south-west of Iran. The composition of the essential oil of was analyzed by gas chromatography-mass spectrometry (GC/MS). Cytotoxic activity was evaluated using MTT assay.   Results: Forty-one components, related to 99.83% of the total oil, were identified. Monoterpene hydrocarbons represented the major components of the volatile oil while α-pinene (73.27%) was the major component. The essential oil showed significant cytotoxic activity against breast cancer cell lines MCF-7 (IC50=0.084 µg/mL), MDA-MB-231 (IC50=0.090 µg/mL) and T-47D (IC50=0.124 µg/mL).  Conclusion: The analysis of J. excelsa oil revealed α-pinene and cedrol as the main compounds of the volatile oil that could justifiy its remarkable cytotoxic effect against the tested cell lines.
کلیدواژه‌های انگلیسی مقاله Cytotoxic, Juniperus excelsa, MTT assay
نویسندگان مقاله Mahnaz Khanavi |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada.

Aysheh Enayati |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Shams Ardekani |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Tahmineh Akbarzadeh |
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Elahe Karimpour Razkenari |
Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Mahdieh Eftekhari |
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_84313_2a2c3985dcb077fc969005753be28bae.pdf
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