این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research Journal of Pharmacognosy، جلد ۶، شماره ۲، صفحات ۹-۱۸
عنوان فارسی Alleviation of Cisplatin-Induced Hepatotoxic Damage: the Synergistic Effect of Morin and Hesperidin against Oxidative Stress
چکیده فارسی مقاله Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), group B (morin), group C (hesperidin), group D (cisplatin), group E (cisplatin+morin), group F (cisplatin+hesperidin), group G (cisplatin+morin+hesperidin). Throughout ten consecutive days, morin and/or hesperidin were given to rats and cisplatin was injected as a single dose (7 mg/kg) on the 4th day, and then the rats were sacrificed on the 11th day. Liver tissue samples collected from the rats were used for the measurement of malondialdehyde, nitric oxide, glutathione levels as well as myeloperoxidase, catalase and superoxide dismutase activities. Results: Administration of cisplatin elevated the malondialdehyde and nitric oxide levels and also reduced the glutathione levels and catalase activity in the liver. However, in the morin and/or hesperidin groups, glutathione level and catalase activity were higher but malondialdehyde and nitric oxide levels and myeloperoxidase activity were lower than the cisplatin-induced group. Conclusion: Our results indicated that pretreatment with these flavonoids can be used as protective treatment for cisplatin-induced hepatotoxicity.
کلیدواژه‌های فارسی مقاله Cisplatin،، hepatotoxicity،، hesperidin،، morin،، oxidative stress،
عنوان انگلیسی Alleviation of Cisplatin-Induced Hepatotoxic Damage: the Synergistic Effect of Morin and Hesperidin against Oxidative Stress
چکیده انگلیسی مقاله Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), group B (morin), group C (hesperidin), group D (cisplatin), group E (cisplatin+morin), group F (cisplatin+hesperidin), group G (cisplatin+morin+hesperidin). Throughout ten consecutive days, morin and/or hesperidin were given to rats and cisplatin was injected as a single dose (7 mg/kg) on the 4th day, and then the rats were sacrificed on the 11th day. Liver tissue samples collected from the rats were used for the measurement of malondialdehyde, nitric oxide, glutathione levels as well as myeloperoxidase, catalase and superoxide dismutase activities. Results: Administration of cisplatin elevated the malondialdehyde and nitric oxide levels and also reduced the glutathione levels and catalase activity in the liver. However, in the morin and/or hesperidin groups, glutathione level and catalase activity were higher but malondialdehyde and nitric oxide levels and myeloperoxidase activity were lower than the cisplatin-induced group. Conclusion: Our results indicated that pretreatment with these flavonoids can be used as protective treatment for cisplatin-induced hepatotoxicity.
کلیدواژه‌های انگلیسی مقاله Cisplatin, hepatotoxicity, hesperidin, morin, oxidative stress
نویسندگان مقاله Kaan Kaltalioglu |
Espiye Vocational School, Giresun University, 28600, Giresun, Turkey

Barbaros Balabanli |
Biology Department, Science Faculty, Gazi University, 06500, Ankara, Turkey

Sule Coskun-Cevher |
Biology Department, Science Faculty, Gazi University, 06500, Ankara, Turkey

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_84314_d0b6352b177b66ef1bc0e4a33661208d.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/338/article-338-1318498.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات