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Research Journal of Pharmacognosy، جلد ۶، شماره ۲، صفحات ۶۷-۷۵
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| عنوان فارسی |
A Stereological and Biochemical Examination: Hepatoprotective Activity of Anthemis odontostephana Boiss. Ethanol Extract Against CCl۴-Induced Hepatotoxicity in Mice |
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| چکیده فارسی مقاله |
Background and objectives: In Iranian traditional medicine, Anthemis odontostephana Boiss has been used in treating gastric ulcers, diabetes, and inflammatory diseases. In the present study, hepatoprotective activity of A. odontostephana ethanol extract (AOEE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in male mice has been evaluated. Methods: In the present experimental study, Sixty male mice were divided into six groups (n=10); Group I was considered as control, received 1 mL/kg olive oil intraperitoneally and 0.5 mL distilled water through gavage. Group II was considered as untreated group, received 1 mg/kg CCl4 mixed with olive oil in the ratio of 1:1, intraperitoneally and 0.5 mL distilled water orally. Group III, IV, V and VI received CCl4 mixed with olive oil in the ratio of 1:1 intraperitoneally and 20, 40, 80 and 160 mg/kg of AOEE through gavage for 45 continuous days. On the last day, the animals of all groups were euthanized and blood and liver were collected for assessing biochemical and histological parameters. The data were analyzed using one-way ANOVA and post-hoc Duncan’s tests. Results: Different doses of AOEE (especially AOEE160) could significantly (p<0.05) decrease the raised volumes of liver sub compartments and the raised levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, low-density lipoprotein (LDL) and increased high-density lipoprotein (HDL), superoxide dismutase (SOD) and catalase (CAT) as compared to the untreated group. Conclusion: According to the obtained results, AOEE can regulate the biochemical parameters and inhibits hepatic damages in CCl4-induced hepatotoxicity in mice. |
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| کلیدواژههای فارسی مقاله |
Anthemis odontostephana Boiss،، ethanol extract،، hepatoprotective activity،، mice، |
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| عنوان انگلیسی |
A Stereological and Biochemical Examination: Hepatoprotective Activity of Anthemis odontostephana Boiss. Ethanol Extract Against CCl4-Induced Hepatotoxicity in Mice |
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| چکیده انگلیسی مقاله |
Background and objectives: In Iranian traditional medicine, Anthemis odontostephana Boiss has been used in treating gastric ulcers, diabetes, and inflammatory diseases. In the present study, hepatoprotective activity of A. odontostephana ethanol extract (AOEE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in male mice has been evaluated. Methods: In the present experimental study, Sixty male mice were divided into six groups (n=10); Group I was considered as control, received 1 mL/kg olive oil intraperitoneally and 0.5 mL distilled water through gavage. Group II was considered as untreated group, received 1 mg/kg CCl4 mixed with olive oil in the ratio of 1:1, intraperitoneally and 0.5 mL distilled water orally. Group III, IV, V and VI received CCl4 mixed with olive oil in the ratio of 1:1 intraperitoneally and 20, 40, 80 and 160 mg/kg of AOEE through gavage for 45 continuous days. On the last day, the animals of all groups were euthanized and blood and liver were collected for assessing biochemical and histological parameters. The data were analyzed using one-way ANOVA and post-hoc Duncan’s tests. Results: Different doses of AOEE (especially AOEE160) could significantly (p<0.05) decrease the raised volumes of liver sub compartments and the raised levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, low-density lipoprotein (LDL) and increased high-density lipoprotein (HDL), superoxide dismutase (SOD) and catalase (CAT) as compared to the untreated group. Conclusion: According to the obtained results, AOEE can regulate the biochemical parameters and inhibits hepatic damages in CCl4-induced hepatotoxicity in mice. |
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| کلیدواژههای انگلیسی مقاله |
Anthemis odontostephana Boiss, ethanol extract, hepatoprotective activity, mice |
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| نویسندگان مقاله |
Mohammad Mahdi Zangeneh |
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Akram Zangeneh |
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Reza Tahvilian |
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Rohallah Moradi |
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Hossein Amiri |
Department of Clinical sciences, Faculty of Veterinary Medicine, Kurdistan Islamic Azad University, Kurdistan, Iran.
Nassim Amiri |
Department of Clinical sciences, Faculty of Veterinary Medicine, Tehran Islamic Azad University, Tehran, Iran.
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| نشانی اینترنتی |
http://www.rjpharmacognosy.ir/article_84325_ed0949e488a1a07f6580fb3b45c2a898.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/338/article-338-1318504.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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