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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۵، صفحات ۴۸۵-۴۹۰
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عنوان انگلیسی Abnormal hippocampal miR-1b expression is ameliorated by regular treadmill exercise in the sleep-deprived female rats
چکیده انگلیسی مقاله Objective(s): The protective effect of regular running on sleep deprivation (SD)-induced cognitive impairment has been revealed. In this study, we focused on the effects of regular exercise, sleep deprivation and both of them together on the microRNA-1b (miR-1b) expression and their relation to the behavioral parameters and brain-derived neurotrophic factor (BDNF) expression. Materials and Methods: We used ovariectomized (OVX) female rats. The exercise program was mild-moderate treadmill training for 4 weeks. 72 hr SD was achieved using the multiple platform method and the spatial learning and memory parameters have been evaluated by the Morris water maze (MWM) test. The levels of studied genes were quantified by real-time PCR.Results: SD down-regulated pri-miR-1b, miR-1b (P˂0.05), and BDNF mRNA (P˂0.01) in the hippocampus. Furthermore, female rats under exercise conditions showed significant up-regulation of the miR-1b and BDNF mRNA (P˂0.001). In addition, miR-1b positively correlated with cognitive function (P˂0.05) and BDNF mRNA (P˂0.01).Conclusion: Our data demonstrated that regular treadmill exercise could reverse the down-regulation of hippocampal miR-1b, which has a probable role in the SD-induced cognitive impairment.
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نویسندگان مقاله | Lily Mohammadipoor-ghasemabad
Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran


| Mohammad Hossein Sangtarash
Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran


| saeed Esmaeili-Mahani
Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran


| Vahid Sheibani
Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran


| Hosein Ali Sasan
Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12574.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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