این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Veterinary Medicine، جلد ۷، شماره ۱، صفحات ۷-۱۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of mesenchymal stem cells with injectable scaffold on cardiac function in myocardial infarction in Rabbit
چکیده انگلیسی مقاله BACKGROUND: Bone marrow-derived mesenchymal cellscan transdifferentiate into Cardiomyocyte cells and improveheart function after transplantation. Since biomaterials canimprove the cell retention in the site, cell survival and differentiation,heart tissue engineering is now being explored as anapplied solution to support cell-based therapies and increasetheir efficacy for myocardial diseases. Chitosan in combinationwith Glycerol Phosphate (GP) can produce a thermo sensitivematerial that in body temperature can form a jellylike material.OBJECTIVES:The aim of this study was to evaluate the effects ofa combination of autologous undifferentiated bone marrowmesenchymal stem cells (MSCs) and injectable scaffold on cardiacfunction improvement in rabbits after inducing myocardialinfarction. METHODS: The Left Anterior Descending (LAD)coronary artery was ligated by No. 6-0 polyamide suturematerial, and autologous MSCs with injectable scaffold wereinjected into the margins of the infarcted zone at the time ofsurgery. At 4 weeks after transplantation, the cardiac functionand structure was detected using echocardiography. RESULTS:There was no significant difference among the three groups (MIonly, MI Scaffold, and MI+Scaffold+MSCs) in the Echocardiographicparameters including, heart rate (HR), Ejection Fraction(EF), Fractional Shortening (FS), Left Ventricular Diameter(LVD) and Left Ventricular Parietal Wall Diameter (LVPW).CONCLUSIONS: A combination of autologous undifferentiatedbone marrow MSCs and injectable scaffold made of Chitosan+Glycerol Phosphate in echocardiographic evaluation did nothave a positive influence on achieving functional improvement.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله نازنین جعفری |
department of clinical sciences, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

محمد مهدی دهقان | mohammad mahdi
department of clinical sciences, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

محمد ابرکار |
department of clinical sciences, faculty of veterinary medicine, islamic azad university, karaj branch, karaj, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمد حجازی |
department of animal sciences, faculty of agriculture, islamic azad university, khorramabad branch, khorramabad, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

پگاه عباس نیا |
department of clinical sciences, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

محمد ملازم |
department of clinical sciences, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

امیر توکلی |
department of clinical sciences, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

روح الله mehdinavaz اقدم | rouh allah mehdinavaz aghdam
nanotechnology department, engineering research institute, tehran, iran

سید حسین احمدی تفتی | seyed hosein ahmadi tafti
tehran heart center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

پرویز تاجیک |
department of clinical sciences, faculty of veterinary medicine, university of tehran, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://ijvm.ut.ac.ir/article_32018_79e1ddedcc421480fe1cdee3769a13ce.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات