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Acta Medica Iranica، جلد ۵۷، شماره ۱، صفحات ۵۷-۶۲
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عنوان انگلیسی Effect of N-Acetylcysteine on Inflammatory and Biochemical Markers of Hemodialysis Patients: A Randomized Controlled Trial
چکیده انگلیسی مقاله The oxidative stress results in atherosclerosis and cardiovascular diseases in patients receiving hemodialysis. N-acetylcysteine is a well-known antioxidant agent. There are little studies about the effect of N-acetylcysteine on patients receiving hemodialysis, and, if any, their results are inconsistent. This study, as a double-blind, randomized clinical trial, was conducted on 44 hemodialysis patients in Shahid Beheshti Hospital, Yasuj, Iran in 2015. Patients were randomly allocated into two groups, in the intervention group, N-acetylcysteine 600 mg every 12 hours for eight weeks was administered and the second group received placebo during this period every 12 hours. Blood samples were taken to measure C-reactive protein, interleukin-6 and other biochemical markers such as ferritin, albumin, and creatinine at baseline and at the end of treatment. 40 patients completed the study (21 on N-acetylcysteine, 19 on placebo), with a mean age of 60.72±17.60. There was not any significant difference between intervention and control groups in interleukin-6 (8.85±6.9 vs. 10.32±8.68, 95% CI, -3.52 to 6.46; P=0.55) and C - reactive protein (0.85±0.29 vs. 0.9±0.31, 95% CI, -.14 to .24; P=0.60). In addition, there was no significant relationship between the two groups in other biochemical markers. In this study, administering N-acetylcysteine was safe and caused a reduction in some inflammatory markers, but these changes were not significant in comparison with placebo.
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نویسندگان مقاله | Rozina Abasi Larki
Department of Nephrology, Yasuj University of Medical Sciences, Yasuj, Iran.


| Alireza Panahi
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.


| Leila Manzouri
Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.


| Moslem Sedaghattalab
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7035
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