| چکیده انگلیسی مقاله |
Hypertriglyceridemia is a common form of dyslipidemia and is associated with several comorbidities, such as increased risk of pancreatitis and cardiovascular diseases (CVD). The white blood cell (WBC) count is a non-specific inflammatory marker associated with a wide variety of diseases such as diabetes, hypertension, and atherosclerotic cardiovascular disease. The objective of this study was to perform a gender-stratified examination of the association between hypertriglyceridemia and hematological parameters in a large sample of Iranian population. The triglyceride (TG) levels and hematological parameters were measured in 9,780 participants (40% males and 60% females) aged 35-65 years, enrolled in a population-based cohort (MASHAD) study in northeastern Iran. Participants were stratified into three groups based on the definition of hypertriglyceridemia: TG< 150 mg/dl (n=6521), TG=150-199 mg/dl (n=1597), and TG≥200 mg/dl (n=1662). A complete blood count (CBC) was obtained for all the subjects. The mean WBC count increased with increasing severity of hypertriglyceridemia among both men and women. Participants with high and very high TG levels had significantly higher WBC count, RBC count, platelet count, hemoglobin, hematocrit, and mean corpuscular hemoglobin concentration and significantly lower RDW. After performing multivariate logistic regression, WBC count and RDW were independently related to hypertriglyceridemia. In conclusion, hypertriglyceridemia is associated with elevated WBC count which may partly explain the observed association between hypertriglyceridemia and CVD. |
| نویسندگان مقاله |
| Alireza Heidari-Bakavoli
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Seyed Mahdi Hassanian
Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. and Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. and Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Amir Avan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. and Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mojtaba Shafiee
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Afsane Bahrami
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
| Maryam Tayefi
Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.
| Samaneh Khakpouri
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Parvin Zamani
Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohsen Moohebati
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mahmoud Ebrahimi
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Farzad Rahmani
Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Habibollah Esmaeili
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohsen Nematy
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. and Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohammad Safarian
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Gordon A. Ferns
Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
| Mahmoud Reza Azarpajouh
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohammad Reza Parizadeh
Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. and Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Majid Ghayour-Mobarhan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran and .Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
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