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Acta Medica Iranica، جلد ۵۵، شماره ۶، صفحات ۳۵۴-۳۵۹

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عنوان انگلیسی Association of the Single Nucleotide Polymorphisms of the Genes Encoding IL-2 and IFN-γ With Febrile Seizure
چکیده انگلیسی مقاله Inflammatory elements and genetics have major roles in febrile seizures (FS) pathogenesis. Seventy patients were enrolled and compared with 139 controls. The allele and genotype frequency of the IL-2 gene at -330 and +166 positions and the IFN-γ at +874 position were determined. A significant positive association with GG genotype at position -330 in the patient group was found (P=0.003). Further, a positive association was detected in simple and complex FS groups at the same position (P=0.03, P=0.004). IL-2 GT haplotype was significantly more common in the patients compared to controls (P=0.0008). Higher frequency of GT haplotype was detected in simple FS patients in comparison to controls (P=0.0003). Contrary, IL-2 TG haplotype frequency was lower in complex FS group (P=0.005). Overrepresentation of certain alleles, genotypes and haplotypes in IL-2 gene in FS patients could predispose individuals to this disease.
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نویسندگان مقاله | Amin Shahrokhi
Pediatric Neurorehabilitation Research Center, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. AND Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.


| Ameneh Zare-Shahabadi
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.


| Mohammad Naeimi Poor
Noor Afshar Hospital, Iranian Red Crescent Society, Tehran, Iran.


| Firouzeh Sajedi
Pediatric Neurorehabilitation Research Center, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.


| Samaneh Soltani
Molecular Immunology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.


| Samaneh Zoghi
Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Vienna, Austria.


| Reza Shervin Badv
Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.


| Mahmoud Reza Ashrafi
Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.


| Nima Rezaei
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, UK.



نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5713
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-1353315.pdf
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