این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Acta Medica Iranica، جلد ۵۳، شماره ۲، صفحات ۸۹-۹۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Chronic lithium treatment increased intracellular S100ß levels in rat primary neuronal culture.
چکیده انگلیسی مقاله S100ß a neurotrophic factor mainly released by astrocytes, has been implicated in the pathogenesis of bipolar disorder. Thus, lithium may exert its neuroprotective effects to some extent through S100ß. Furthermore, the possible effects of lithium on astrocytes as well as on interactions between neurons and astrocytes as a part of its mechanisms of actions are unknown. This study was undertaken to determine the effect of lithium on S100β in neurons, astrocytes and a mixture of neurons and astrocytes. Rat primary astrocyte, neuronal and mixed neuro-astroglia cultures were prepared from cortices of 18-day's embryos. Cell cultures were exposed to lithium (1mM) or vehicle for 1day (acute) or 7 days (chronic). RT-PCR and ELISA determined S100β mRNA and intra- and extracellular protein levels. Chronic lithium treatment significantly increased intracellular S100β in neuronal and neuro-astroglia cultures in comparison to control cultures (P
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Masoumeh Emamghoreishi
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Fars, Iran. AND Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Fars, Iran. AND Psychiatric Research Centre, School of Medicine, Shiraz University of Medical Sciences, Fars, Iran.


| Mojtaba Keshavarz
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Fars, Iran.


| Ali Akbar Nekooeian
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Fars, Iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/4930
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-1353362.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات