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Journal of Arthropod-Borne Diseases، جلد ۱۱، شماره ۱، صفحات ۱۹-۲۶
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عنوان انگلیسی Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
چکیده انگلیسی مقاله Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflamma­tory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. Methods: Thirty cases younger than 17 yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the pa­tient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA. Results: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05).  A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parame­ters and VEGF and HIF-1α in the patient group (P< 0.05) Conclusion: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis.
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نویسندگان مقاله | Murat Sefikogullari
Pediatric Clinic, Private Samanda&#x11F; Medical Center, Hatay, Turkey


| Ali Kaya
Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey


| Huseyin Aydin
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey


| Enver Sancakdar
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey


| Veysel Kenan Celik
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey


| Gokhan Bagci
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/387
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