این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۴۸، شماره ۳، صفحات ۴۳۵-۴۴۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Prevalence of the Potential Drug-Drug Interactions Involving Anticancer Drugs in China: A Retrospective Study
چکیده انگلیسی مقاله Abstract Background: To survey the prevalence of potential drug-drug interactions (DDIs) between anticancer drugs and non-anticancer drugs and evaluate the risk factors associated with these drug-drug interactions in China. Methods: All discharged patients in the Department of Oncology were collected from Jun to Dec in 2016 with the Hospital Information System of the Chinese people’s Liberation Army General Hospital. Drugs were screened for interactions by Micromedex solutions database. Descriptive statistics were generated and logistic regression was used to identify the associated factors. Results: Among 6578 eligible patients, 1979 potential drug interactions were found in 1830 patients (27.82%). The most common drug-drug interaction was cisplatin and furosemide. Erlotinib was most likely to interact with various non-anticancer drugs. Most interactions were classified as pharmacodynamics (71.60%), major severity (97.02%) and were supported by fair documentation evidence (86.21%). In multivariate analysis, increasing number of medications, lung cancer and patients with stage IV had a higher risk for potential drug-drug interactions. Conclusion: Potential drug-drug interactions between antineoplastic drugs and non-antineoplastic drugs occur frequently in cancer patients of Chinese hospitals. Doctors should fully consider potential risk associated with DDIs. Further research should be performed to evaluate real clinical significance of these drug-drug interactions.  
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Weilan WANG
Department of Pharmacy, General Hospital of People's Liberation Army (PLA), Beijing, 100853, China


| Bingkun XIAO
Department of Pharmacochemistry, Institute of Radiation Medicine, Beijing, 100850, China


| Ziqi LIU
Department of Pharmacy, General Hospital of People's Liberation Army (PLA) Rocket Force, Beijing, 100088, China


| Dongxiao WANG
Department of Pharmacy, General Hospital of People's Liberation Army (PLA), Beijing, 100853, China


| Man ZHU
Department of Pharmacy, General Hospital of People's Liberation Army (PLA), Beijing, 100853, China
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/16519
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1353994.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات