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Iranian Journal of Public Health، جلد ۴۷، شماره ۱۲، صفحات ۱۸۱۶-۱۸۲۱
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عنوان انگلیسی Antifungal Susceptibility of Candida Species Isolated from Horticulturists with Onychomycosis in Piauí, Brazil
چکیده انگلیسی مقاله Background: We aimed to assess susceptibility pattern of Candida species isolated from horticulturists with onychomycosis to four antifungal drugs and to compare the effectiveness of conventional identification methods with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS). Methods: This study was conducted in a community garden located in Teresina, State of Piauí, Brazil, in the year 2014. The samples were identified through phenotypic methods and per MALDI-TOF MS, being used PCR as definitive identification test. The susceptibility pattern to four antifungal drugs was determined according to Clinical and Laboratory Standards Institute (CLSI). Results: Fourteen clinical isolates from seven different species were identified by the phenotypic method and by MALDI-TOF MS, with an observed concordance of 71.4% between the two methods. C. albicans (28.6%), C. parapsilosis (21.4%), C. guilliermondii and C. metapsilosis (both with 14.3%) were the most frequent species. With the exception of C. krusei, all species were sensitive to the tested antifungal. Conclusion: This is the first study of antifungal susceptibility of Candida in Piauí, Brazil. With the exception of C. krusei, no species showed resistance to the antifungal drugs used. This study suggests constants updates from the public databases used in MALDI-TOF MS to provide a rapid and accurate mycological diagnosis.  
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نویسندگان مقاله | Mitra MOBIN
Research Laboratory, University Center UNINOVAFAPI, Teresina, Brazil


| Maria Walderez SZESZS
Nucleus Mycology, Adolfo Lutz Institute, São Paulo, Brazil


| Juliana Possatto TAKAHASHI
Nucleus Mycology, Adolfo Lutz Institute, São Paulo, Brazil


| Marilena MARTINS
Nucleus Mycology, Adolfo Lutz Institute, São Paulo, Brazil


| Daise Damaris Carnietto de HIPPÓLITO
Nucleus Mycology, Adolfo Lutz Institute, São Paulo, Brazil


| Jhonatas Cley Santos PORTO
Research Laboratory, University Center UNINOVAFAPI, Teresina, Brazil


| João Batista TELES
Research Laboratory, University Center UNINOVAFAPI, Teresina, Brazil


| Sidney Gonçalo de LIMA
Science Center of Nature, Department of Chemistry, Federal University of Piauí, Teresina, Brazil


| Marcia de Souza Carvalho MELHEM
Nucleus Mycology, Adolfo Lutz Institute, São Paulo, Brazil
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/15507
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1354073.pdf
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