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Iranian Journal of Public Health، جلد ۴۷، شماره ۱۰، صفحات ۱۴۵۳-۱۴۵۷
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عنوان انگلیسی Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article
چکیده انگلیسی مقاله Abstract Background: The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive biomarkers and personalized medicine. Methods: Scientific databases were searched to collect relative data. Results: Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor- normal comparisons can be performed using NGS in order to diagnosis of several types of cancer. Conclusion: NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner.  
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نویسندگان مقاله | Faezeh SHABANI AZIM
Student Scientific Research Center, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran


| Hamidreza HOURI
Dept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Zohreh GHALAVAND
Dept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Bahram NIKMANESH
Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran, 2-Dept. of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/14905
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1354132.pdf
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