این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۴۷، شماره ۴، صفحات ۵۱۰-۵۱۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on Maintenance Hemodialysis
چکیده انگلیسی مقاله Background: We aimed to investigate the relationship between serum soluble Klotho protein (sKlotho) level and coronary artery calcification (CAC) as well as prognosis in patients with maintenance hemodialysis (MHD). Methods: Overall, 128 adult patients with end-stage renal failure treated with MHD were collected in the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Province, China in 2013. Serum sKlotho was detected by ELISA and coronary artery calcification was measured by multi-slice spiral computed tomography (MSCT). With 36 months' follow-up, death notes such as cause of death and death time were recorded. Results: Patients were divided into low sKlotho group and high sKlotho group. Age, blood phosphorus level, hypertension incidence and incidence of diabetes mellitus of the patients in low sKlotho group was significantly higher than that of high sKlotho group (P< 0.05). The coronary artery calcification score (CACs) of patients in high sKlotho group was significantly lower than that of low sKlotho group (P< 0.001). Logistic regression showed that the decrease of sKlotho level (P< 0.001) was an independent risk factor for CAC progression. The mortality of the patients in low sKlotho group was higher than that of high sKlotho group. Kaplan-Meier survival curve had shown that survival time of the patients in low sKlotho group was significantly lower than that of high sKlotho group (P< 0.05). Conclusion: SKlotho can increase the degree of CAC. Although MHD patients with low sKlotho level had shorter survival time, sKlotho is not an independent risk factor in prediction of prognosis of MHD patients.  
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Shubei ZHENG
Dept. of Nephrology, The Second Affiliated Hospital & Yuying Children&#x2019;s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China


| Yu ZHENG
Dept. of Nephrology, The Second Affiliated Hospital & Yuying Children&#x2019;s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China


| Lingwei JIN
Dept. of Nephrology, The Second Affiliated Hospital & Yuying Children&#x2019;s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China


| Zhihong ZHOU
Dept. of Nephrology, The Second Affiliated Hospital & Yuying Children&#x2019;s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China


| Zhanyuan LI
Dept. of Nephrology, The Second Affiliated Hospital & Yuying Children&#x2019;s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/13145
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1354219.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات