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Iranian Journal of Public Health، جلد ۴۵، شماره ۱۱، صفحات ۱۴۶۵-۱۴۷۲
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عنوان انگلیسی Various Effects of Omega 3 and Omega 3 Plus Vitamin E Supplementations on Serum Glucose Level and Insulin Resistance in Patients with Coronary Artery Disease
چکیده انگلیسی مقاله Background: Omega 3 and vitamin E are two critical nutrients which include beneficial effects in coronary artery disease (CAD). The aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin E on serum glucose and lipid levels and insulin resistance in CAD patients. Methods: Participants of this clinical trial included 60 male patients with CAD who selected from Tehran Heart Center in Tehran, Iran in 2014. They received 4 g/day omega 3 plus 400 IU/day vitamin E (OE), 4 g/day omega 3 with vitamin E placebo (OP), or omega 3 and vitamin E placebo (PP) for two months. Serum glucose, lipids and insulin were assessed and HOMA-IR was calculated before and after the trial and effects of these nutrients on the highlighted parameters were compared within the study groups. Results: Serum glucose level increased significantly in OP group (P=0.004), but not in OE group. OE and OP groups showed a significant decrease in fasting serum TG (P=0.020 and P=0.001, respectively). Serum insulin and HOMA-IR decreased significantly in OE group (P=0.044 and P=0.039, respectively) but did not change significantly in OP group. Conclusion: Although, omega 3 supplementation may include adverse effects on serum glucose level, co-administration of omega 3 and vitamin E can beneficially decrease serum insulin and insulin resistance in CAD patients.    
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نویسندگان مقاله | Somayeh SABOORI
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran 
 Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran


| Mahmoud DJALALI
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran


| Esmaeil YOUSEFI RAD
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran


| Ebrahim Nematipour
Dept. of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran


| Ali Akbar SABOOR-YARAGHI
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Hassan JAVANBAKHT
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Reza ESHRAGHIAN
Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Atena RAMEZANI
Dept. of Basic Sciences and Nutrition, Cardiovascular Research Center, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran


| Fariba KOOHDANI
Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran 
 Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/8348
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1354372.pdf
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