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Iranian Journal of Public Health، جلد ۴۳، شماره ۶، صفحات ۸۲۱-۷
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عنوان انگلیسی Analysis of MTHFR Gene C.677C>T and C.1298A>C Polymorphisms in Iranian Patients with Non-Syndromic Cleft Lip and Palate.
چکیده انگلیسی مقاله Non-syndromic cleft lip with or without cleft palate (nsCL/P) is one of the most common congenital abnormalities of the orofacial region with a multifactorial etiology. The present study aimed to investigate the association of two common polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene (c.677C>T and c.1298A>C) with the occurrence of nsCL/P in an Iranian population.Forty-five nsCL/P patients, 43 mothers of patients, and 101 unrelated controls participated in the present study. Analysis of c.677C>T and c.1298A>C polymorphisms in MTHFR gene was conducted using polymerase chain reaction and restriction enzyme digestions.There was no statistical difference in genotype and allele frequencies for c.677C>T variants between patients or their mothers and the control group. However, differences in the frequencies of alleles and genotypes of c.1298A>C polymorphism were statistically significant between patients and control group (P=0.01 for alleles and P=0.005 for genotypes). The odds ratios (OR) for the CC versus AA homozygotes were 6.1 (95% CI 1.8-20.5) and 4.2 (95% CI 1.1-15.4), in patients and mothers, respectively.We found no association between genetic polymorphism of MTHFR c.677C>T and the risk of nsCL/P in the population studied. Yet the results suggested that c.1298A>C polymorphism of MTHFR gene may be a risk factor for the occurrence of nsCL/P in the Iranian population.
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نویسندگان مقاله | Arezoo Jahanbin
1. Dept. of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences , Mashhad, Iran.


| Nadia Hasanzadeh
2. Dental Material Research Center, School of Dentistry, Mashhad University of Medical Sciences , Mashhad, Iran.


| Faraneh Abdolhoseinpour
3. Mashhad University of Medical Sciences , Mashhad, Iran.


| Ariane Sadr-Nabavi
4. Dept. of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran.


| Mohammad-Ali Raisolsadat
5. Dr. Sheikh Hospital, Mashhad University of Medical Sciences , Mashhad, Iran.


| Khosro Shamsian
6. Jahade Daneshgahi of Mashhad , Mashhad, Iran.


| Farnaz Mohajertehran
7. Dental Research Center, Mashhad University of Medical Sciences , Mashhad, Iran.


| Hamidreza Kianifar
8. Dept. of Pediatric Gastroenterology, Ghaem Medical Center, Mashhad University of Medical Sciences , Mashhad, Iran.
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/4054
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