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Journal of Family and Reproductive Health، جلد ۱۲، شماره ۱، صفحات ۸-۱۷
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عنوان انگلیسی Role of Aqueous Crude Leaf Extract of Senecio Biafrae Combined With Zinc on Testicular Function of Adult Male Sprague Dawley Rats
چکیده انگلیسی مقاله Objective: To determine the role of aqueous crude leaf extract of Seneciobiafrae (SB) combined with Zinc (Zn) on Testicular function of Adult Male Sprague dawley Rats. Materials and methods: Twenty-four adult males praguedawley Rats weighing 180-200g, aged 10-12 weeks, were randomized into four groups (A,B,C,D) of six rats each (n = 6) and were given 2mls of distilled water; 500 mg/kg of SB ; 500 mg/kg of SB and 0.5 mg/kg Znsulfate; 500 mg/kg of SB and 1mg/kg of Zn. The administration was done daily via gastric gavage for 28 days. Parameterstested include: testicular histology, sperm parameters, haematological parameters and Testosterone assay. Results: There was observed no significant (p > 0.05) increased in testis, epididymal, seminal vesicle, vas deference and prostate gland weight of animals across the group receiving the Seneciobiafrae extract combine with Zn. Testis and serum testosterone levels, sperm count, percentage of sperm viability and motility was higher in the rats administered a combination of Seneciobiafrae extract and Zn compared with controls (p < 0.05). Conversely the percentage of abnormal sperm morphology was decreased (p < 0.05). Histological analysis showed normal spermatogenesis, better association and high density of spermatogenic cells and lumen contains full mature spermatozoa. Conclusion: Aqueous extract of Seneciobiafrae combined with Zn, potentially enhance testicular function including steroidogenesis and spermatogenesis in male rats.
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نویسندگان مقاله | Sunday Adelakun
Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria AND Department of Anatomy, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria


| Babatunde Ogunlade
Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria


| Olusegun Omotoso
Department of Anatomy, Kogi State University, Anyigba, Kogi State, Nigeria


| Oyebowale Oyewo
Department of Anatomy, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
نشانی اینترنتی http://jfrh.tums.ac.ir/index.php/jfrh/article/view/747
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