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Journal of Pharmaceutical Care، جلد ۱، شماره ۳، صفحات ۸۱-۸۴
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عنوان انگلیسی Prevention of Stress Related Mucosal Disease with Intermittent
چکیده انگلیسی مقاله Background: This study aimed to compare intermittent intravenous (IV) pantoprazole and ranitidine for control of gastric acid secretion and the possible prevention of Upper Gastrointestinal Bleeding (UGIB) in critical care patients. Methods: This was a randomized, double blind clinical trial study of IV pantoprazole (40 mg every12 hour) or intermittent IV ranitidine (50 mg bolus every 8 hour) in patients at risk for UGIB. The primary endpoint was gastric pH. UGIB was measured as secondary endpoint. Results: ninety two Critical care patients were enrolled. Gastric pH was well controlled by two study drugs. Gastric pH increased in pantoprazole group than in the ranitidine group (4.40±0.39 versus 3.32±0.28; P=0.000). Upper GI bleeding was higher in ranitidine group than pantoprazole group (4/46 versus 2/46; P=0.404). Conclusion: This  study  indicates  that  intermittent  IV pantoprazole  compared  with  bolus  IV ranitidine, more effectively controls gastric pH and may prevent UGIB in high risk critical care patients without the development of tolerance.
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نویسندگان مقاله | Farshid Rahimi-Bashar
Assistant Professor, Department of Anesthesiology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.


| Alireza Rastgouyhaghi
Assistant Professor, Department of Pathology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.


| Saadat Torabian
Assistant Professor, Department of Community Medicine, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.


| MohammadReza Hajiesmaeili
Fellow in Critical Care Medicine, Parsian Hospital, Tehran, Iran.


| Alireza Sedaghat
Assistant Professor, Department of Anesthesiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Shahram Seifi
Assistant Professor, Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.


| Mahdis Solhjoo
General practitioner, Qazvin University of Medical Sciences, School of Medicine, Qazvin, Iran.
نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/19
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