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Journal of Craniomaxillofacial Research، جلد ۵، شماره ۲، صفحات ۷۹-۸۴
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عنوان انگلیسی Immunohistochemical expression of SOX2 in oral normal epithelial, dysplasia and squamous cell carcinoma
چکیده انگلیسی مقاله Objective: Oral squamous cell carcinoma (SCC) is an aggressive neoplasm with serious morbidity and mortality, which typically spreads through local invasive growth. A key approach to this tumor would be to detect potentially malignant lesions at their early stages. The transcription factor, Sex determining region Y-box  2 (SOX2) is an essential regulator of pluripotent stem cells and promotes developmentand maintenance  of squamous epithelia. Materials and Methods: We retrospectively reviewed the charts of 24 samples of SCC, oral epithelial dysplasia and control group, then immunohistochemical staining was performed to detect SOX2 expression. Results: Comparisons between SCC and oral epithelial dysplasia group did not reveal any significant difference (p=0.496); also values of control and oral epithelial dysplasia group were statically different (p< 0.001). Similarly, a significant difference was observed between the values of SCC and controls’ (p< 0.001). Conclusion: In conclusion, SOX2 overexpression is seen in oral dysplasia and SCC and their detection in early  stages could be crucial for early tumor identification.
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نویسندگان مقاله | Pouria Motahhary
Oral and Maxillofacial Pathologist, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.


| Mahnaz Sahebjamee
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.


| Maryam Nasimi
Department of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Zohreh Khodashenas
Student of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Fatemeh Hajian
Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.


| Kambiz Kamyab
Department of Dermatopathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://jcr.tums.ac.ir/index.php/jcr/article/view/204
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