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Acta Medica Iranica، جلد ۵۰، شماره ۴، صفحات ۲۲۶-۲۳۲
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عنوان انگلیسی The Effects of Cyclosporin-A on Functional Outcome and Axonal Regrowth Following Spinal Cord Injury in Adult Rats
چکیده انگلیسی مقاله It has been shown that the immunophilin ligands have the special advantage in spinal cord repair. In this study, the effects of cyclosporine A (CsA) on functional recovery and histological outcome were evaluated following spinal cord injury in rats. After spinal cord hemisection in thirty six adult female Sprague-Dawley rats (200- 250 g), treatment groups received CsA (2.5 mg/kg i.p.) at 15min and 24h after lesion (CsA 15min group and CsA 24h group) daily, for 8 weeks. Control and sham groups received normal saline and in sham operated animals the spinal cord was exposed in the same manner as treatment groups, but was not hemisected. Hindlimb motor function was assessed in 1, 3, 5 and 7 weeks after lesion, using locomotive rating scale developed by Basso, Bresnahan and Beattie (BBB). Motor neurons were counted within the lamina IX of ventral horn and lesion size was measured in 5 mm of spinal lumbar segment with the epicenter of the lesion site. The mean number of motor neurons and the mean BBB scale in 3, 5 and 7 weeks in CsA 15min groups significantly increased compared to the control group. Although, the lesion size reduced in rats with CsA treatment compared to the control group, no significant difference was observed. Thus, it can be concluded that CsA can improve locomotor function and histological outcome in the partial spinal cord injury.
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نویسندگان مقاله | Amrollah Roozbehi
Cellular and Molecular Research Center, Faculty of Medicine, Yasuj University of Medical Sciences, Yasouj, Iran.


| Mohammad Taghi Joghataie
Department of Anatomy, Cellular and Molecular Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Mehdi Mehdizadeh
Department of Anatomy, Cellular and Molecular Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Ali Mirzaei
Department of Biochemistry, Cellular and Molecular Research Center, Faculty of Medicine, Yasuj University of Medical Sciences, Yasouj, Iran.


| Hamdollah Delaviz
Cellular and Molecular Research Center, Faculty of Medicine, Yasuj University of Medical Sciences, Yasouj, Iran
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/3889
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-1358730.pdf
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