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Caspian Journal of Enviromental Sciences، جلد ۱۷، شماره ۱، صفحات ۴۳-۵۳
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عنوان انگلیسی Effects of xenostrogen treatment (4-Nonylphenol, Bisphenol A) on vitellogenin expression in juvenile Cyprinus carpio
چکیده انگلیسی مقاله The aim of this study was to examine some potential effects of 4-Nonylphenol (4-NP), Bisphenol A (BPA), and mixture of them on common carp, Cyprinus carpio and demonstrate induction of vitellogenin (Vtg) as a biomarker for screening aquatic ecosystems. These compounds with other estrogenic chemicals may be responsible for disrupting effects observed in fish. A total of 100 juvenile carp were treated experimentally with 17β-estradiol (E2), and increasing doses of 4-NP, BPA and also mixture of them. Then the plasma Vtg levels were measured using indirect competitive ELISA. Results showed a significant (P< 0.05) increase in Vtg levels of exposed carps with E2, maximum 4-NP, BPA and their mixture. The group treated with E2 showed high induction (490%) with respect to controls. The groups treated with maximum dose of 4-NP and BPA showed also induction of Vtg, whereas the group treated with their mixture (3 mg kg−1 b.w. 4-NP and 0.01 mg kg−1 b.w. BPA) showed the highest induction (2126%). Finally, results showed that mixture of 4-NP and BPA exhibited stronger (synergistic) effects. So that, large scale monitoring of estrogenic effects caused by contamination may be considered as a biomarker in urban and industrial effluents.
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نویسندگان مقاله S Mortazavi |
Department of Environmental Sciences, Faculty of Natural Resource and Environment, Malayer University, Hamedan, Iran

A.R Riyahi Bakhtiari |
Department of Environmental Sciences, Faculty of Natural Resource and Marine Science, Tarbiat Modares University, Noor, Mazandaran, Iran

A Esmaili Sari |
Department of Environmental Sciences, Faculty of Natural Resource and Marine Science, Tarbiat Modares University, Noor, Mazandaran, Iran

F Rahbarizadeh |
Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

N Hassanzadeh |
Department of Environmental Sciences, Faculty of Natural Resource and Environment, Malayer University, Hamedan, Iran

نشانی اینترنتی https://cjes.guilan.ac.ir/article_3343_de06f19721dc53a5719f12ffce4f56d2.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/385/article-385-1383087.pdf
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زبان مقاله منتشر شده en
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