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Journal of Sciences Islamic Republic of Iran، جلد ۲۷، شماره ۱، صفحات ۲۳-۲۹
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عنوان انگلیسی Direct Bisulfite Sequencing and Methylation Specific PCR to Detect Methylation of p15INK4b and F7 genes in Coronary Artery Disease Patients
چکیده انگلیسی مقاله Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the extrinsic pathway by the exposure of tissue factor after plaque disruption is related to atherothrombosis. The aim of the present study was to evaluate methylation status of two CAD related genes, p15INK4b and F7, in Iranian patients with coronary artery disease (CAD). Thirty samples from 15 male and 15 female with diagnosed 3 vessels disease CAD and 60 Samples from 60 non-CAD controls who underwent coronary angiography was analyzed by MSP and direct sequencing. DNA methylation levels at p15INK4b gene increased significantly in CAD patients in comparison with control group (p-value
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله m یاری |
1 department of medical genetics, faculty of medicine, university of shahid beheshti medical sciences, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

a موفق |
1 department of medical genetics, faculty of medicine, university of shahid beheshti medical sciences, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

a صیاد |
1 department of medical genetics, faculty of medicine, university of shahid beheshti medical sciences, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

م دیوید عمرانی | m d
1 department of medical genetics, faculty of medicine, university of shahid beheshti medical sciences, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

محمدعلی برومند | m a
2 department of molecular pathology, tehran heart center, university of tehran medical sciences, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

k مجیدزاده اردبیلی | majidzadeh a
3 department of breast cancer genetics, breast cancer research center bcrc , university of tehran, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

r میرفخرایی |
1 department of medical genetics, faculty of medicine, university of shahid beheshti medical sciences, tehran, islamic republic of iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

a خوشدل |
4 department of medical sciences, faculty of medicine, university of aja, tehran, islamic republic of iran.

k امینی |
4 department of medical sciences, faculty of medicine, university of aja, tehran, islamic republic of iran.

نشانی اینترنتی http://jsciences.ut.ac.ir/article_56005_e24ebf02e8a108a49701ab41119c5dac.pdf
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