این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Sciences Islamic Republic of Iran، جلد ۲۲، شماره ۲، صفحات ۱۱۱-۱۱۶
عنوان فارسی Association of CCR۲ Gene but not CCR۵ Gene Polymorphisms with Alzheimer’s Disease
چکیده فارسی مقاله Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells. Chemokines and their receptors are therefore considered to mediate inflammation and tissue damage in autoimmune disorders. The recent studies have revealed the genotypes of chemokine receptors (CCR) and their related polymorphisms in a number of autoimmune and infectious diseases. We used the polymorphic DNA markers (CCR2-64I) and (CCR5?32) to study the association of CCR2 and CCR5 gene mutations with Late-onset Alzheimer’s disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and genotype frequencies were statistically determined. No significant linkage was determined between CCR5?32 and the disease of interest. However the gene CCR2 was appeared to be significantly linked to the disease, as it could be concluded from statistical analysis.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association of CCR2 Gene but not CCR5 Gene Polymorphisms with Alzheimer’s Disease
چکیده انگلیسی مقاله Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells. Chemokines and their receptors are therefore considered to mediate inflammation and tissue damage in autoimmune disorders. The recent studies have revealed the genotypes of chemokine receptors (CCR) and their related polymorphisms in a number of autoimmune and infectious diseases. We used the polymorphic DNA markers (CCR2-64I) and (CCR5?32) to study the association of CCR2 and CCR5 gene mutations with Late-onset Alzheimer’s disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and genotype frequencies were statistically determined. No significant linkage was determined between CCR5?32 and the disease of interest. However the gene CCR2 was appeared to be significantly linked to the disease, as it could be concluded from statistical analysis.
کلیدواژه‌های انگلیسی مقاله Alzheimer’s disease, CCR5, CCR2
نویسندگان مقاله سید محمد محدث اردبیلی | s m mohaddes ardebili
department of medical genetics, faculty of medicine, tabriz university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://jsciences.ut.ac.ir/article_23033_8c7093c79ee7cb5ad3fe71dd27851e1d.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات