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Journal of Sciences Islamic Republic of Iran، جلد ۲۲، شماره ۱، صفحات ۲۷-۵۷
عنوان فارسی Synthesis and in vitro Antibacterial Activity of Some Novel ۲-Amino-۴, ۶-D Derivatives
چکیده فارسی مقاله Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. Keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. Eight novel 2-amino-4,6-diarylpyrimidine derivatives have been prepared by condensation of chalcone derivatives with guanidine hydrochloride. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR spectra, 1H NMR and Mass spectral data. These compounds were screened for their antibacterial activity. The recorded zone of inhibition showed significant antibacterial activity when compared with reference standard Sparfloxacin.
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عنوان انگلیسی Synthesis and in vitro Antibacterial Activity of Some Novel 2-Amino-4, 6-D Derivatives
چکیده انگلیسی مقاله Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. Keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. Eight novel 2-amino-4,6-diarylpyrimidine derivatives have been prepared by condensation of chalcone derivatives with guanidine hydrochloride. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR spectra, 1H NMR and Mass spectral data. These compounds were screened for their antibacterial activity. The recorded zone of inhibition showed significant antibacterial activity when compared with reference standard Sparfloxacin.
کلیدواژه‌های انگلیسی مقاله 41-Piperazine acetophenone, Pyrimidines, Guanidine and Sparfloxacin
نویسندگان مقاله سید علی رخمن | s a
nirmala college of pharmacy

نشانی اینترنتی http://jsciences.ut.ac.ir/article_22211_6461e9c3563fc4add0f569dbefa940c3.pdf
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