این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Molecular Biology Research Communications، جلد ۴، شماره ۲، صفحات ۹۳-۱۰۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Analysis of the enzyme network involved in cattle milk production using graph theory
چکیده انگلیسی مقاله Understanding cattle metabolism and its relationship with milk products is important in bovine breeding. A systemic view could lead to consequences that will result in a better understanding of existing concepts. Topological indices and quantitative characterizations mostly result from the application of graph theory on biological data. In the present work, the enzyme network involved in cattle milk production was reconstructed and analyzed based on available bovine genome information using several public datasets (NCBI, Uniprot, KEGG, and Brenda). The reconstructed network consisted of 3605 reactions named by KEGG compound numbers and 646 enzymes that catalyzed the corresponding reactions. The characteristics of the directed and undirected network were analyzed using Graph Theory. The mean path length was calculated to be 4.39 and 5.41 for directed and undirected networks, respectively. The top 11 hub enzymes whose abnormality could harm bovine health and reduce milk production were determined. Therefore, the aim of constructing the enzyme centric network was twofold; first to find out whether such network followed the same properties of other biological networks, and second, to find the key enzymes. The results of the present study can improve our understanding of milk production in cattle. Also, analysis of the enzyme network can help improve the modeling and simulation of biological systems and help design desired phenotypes to increase milk production quality or quantity.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شعله قربانی |
ferdowsi university of mashhad, mashhad, khorasan, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

مجتبی طهمورث پور |
ferdowsi university of mashhad, mashhad, khorasan, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

علی مسعودی نژاد | masoudi nejad
institute of biochemistry and biophysics, university of tehran, tehran, iran
سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

محمدرضا نصیری | mohammad reza
ferdowsi university of mashhad, mashhad, khorasan, iran.
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

یزدان عسگری |
institute of biochemistry and biophysics, university of tehran, tehran, iran
سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_3007_d804f752a9af08cc3ccafcfb0d4ae4f2.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات