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Molecular Biology Research Communications، جلد ۳، شماره ۴، صفحات ۲۱۵-۲۲۲
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عنوان انگلیسی Identification and characterization of major histocompatibility complex class IIB alleles from three species of European ranid frogs
چکیده انگلیسی مقاله Immune genes of the major histocompatibility complex (MHC) are among the most polymorphic genes in the vertebrate genome. Due to their polymorphic nature, they are often used to assess the adaptive genetic variability of natural populations. This study describes the first molecular characterization of 13 partial MHC class IIB sequences from three European ranid frogs. The utility of previously published primers was expanded by using them to successfully amplify eight exon 2 alleles from Rana arvalis. We also designed a novel primer set that successfully amplified exon 2 from Pelophylax kurtmuelleri. Pelophylax lessonae was also designed as part of this study. Results indicate the presence of one or two class IIB loci in these three species. In R. arvalis, significant evidence of positive selection acting on MHC antigen binding sites was found. Many European ranid populations are experiencing disease-related declines; the newly developed primers can, therefore, be used for further population analyses of native frogs.
کلیدواژه‌های انگلیسی مقاله Antigen Binding Site,Anura,Pelophylax,Rana,Ranidae
نویسندگان مقاله béla a محمد | béla a marosi
department of parasitology, university of agricultural science and veterinary medicine, mănăștur street nr. 3-5, ro-400372 cluj-napoca, romania

کارن m kiemnec tyburczy | m kiemnec tyburczy
department of biological sciences, humboldt state university 95521 usa

یان v ghira | v ghira
faculty of biology and geology, babes-bolyai-university cluj-napoca, clinicilor street 5-7, ro-400006 cluj-napoca, romania

tibor sos |
association for bird and nature protection amp;amp;ldquo;milvus group amp;amp;rdquo;, targu mures, 22 crinului street, ro-540343

octavian popescu |
molecular biology center, interdisciplinary research institute on bio-nano-sciences, babes-bolyai university cluj-napoca, 42 treboniu laurian street, ro-400271 cluj-napoca, romania

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_2486_8506b1334d9f2c95d43d0d9204ee6d62.pdf
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