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Molecular Biology Research Communications، جلد ۲، شماره ۴، صفحات ۱۰۱-۱۰۷
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عنوان انگلیسی Effects of Teucrium polium aerial parts extracts on malonyl-CoA decarboxylase level
چکیده انگلیسی مقاله Malonyl-CoA decarboxylase (MCD) is an enzyme involved in the decarboxylation of malonyl-CoA to acetyl-CoA. In order to explore the hypothesis that the changing plant materials’ MCD activity level can serve as therapy to diabetics, the effect of Teucrium polium compounds was studied in a diabetic rat model. In this experimental study, two groups of rats, a control and a diabetic group, each including six rats, were used. At the end of the experiment, all rats were exterminated by ether anesthesia, their pancreases removed and dissected. Isolated rat pancreas was cultured in buffers with or without 100-500µg/l T. polium aerial parts extracts containing arginine and leucine. MCD and insulin levels were measured after culture at 37°C and 5% CO2, for 1, 3 and 5 days. Results showed that T. polium aqueous and the alcoholic extract decreased MCD activity. Present data also indicate that incubation of pancreatic tissue at a concentration of 2.8 and 16.7 mmol/L glucose stimulated insulin release. For the first time it seems that aqueous and alcoholic extracts of this plant decreased MCD activity. 
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نویسندگان مقاله دردی قوجق |
cellular and molecular biology research center cmbrc , babol university of medical sciences, babol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

محسن تاتار |
department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

فریده فیضی |
department of anatomical sciences, faculty of medicine, babol university of medical sciences, babol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

هادی پارسیان |
cellular and molecular biology research center cmbrc , babol university of medical sciences, babol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

سهراب حلال خور |
department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_1751_2fc27ab19c8164922fd835e15f1455dd.pdf
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