این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Molecular Biology Research Communications، جلد ۲، شماره ۱-۲، صفحات ۱-۱۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی PLLA/HA Nano composite scaffolds for stem cell proliferation and differentiation in tissue engineering
چکیده انگلیسی مقاله Abstract Due to their mulitpotency, Mesenchymal stem cells (MSCs), have the ability to proliferate and differentiate into multiple mesodermal tissues. The aim of this study was to isolate MSCs from human Umbilical Cord (hUCMSCs) to determine their osteogenic potential on nanofibrous scaffolds. To this end, Poly (L-lactic acid) (PLLA)/Nano hydroxyapatite (HA) composite nanofibrous scaffolds were prepared by electrospinning. The structure and morphology of the scaffolds were investigated using scanning electron microscopy. Human mesenchymal stem cells (MSCs) were isolated from the umbilical cords and cultured in the PLLA/HA scaffold. The viability and proliferation of the cells was then determined by an MTT assay. Cellular adhesion, proliferation and osteogenic differentiation were assessed in these constructs using a range of histological and microscopic techniques. The osteogenesis assays indicated the superiority of nanofibrous scaffolds in supporting MSCs undergoing bone differentiation. Collectively, the bone construct prepared with PLLA/HA scaffold and proliferated MSCs would be a suitable candidate for use in bone regenerative medicine. Keywords: hUCMSCs; nanofibrous scaffolds; hydroxyapatite; PLLA; Cell proliferation; Bone differentiation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فریبا منصوری زاده |
department of biology, university of kharazmi, tehran, iran

اسدالله اسدی |
department of biology, faculty of science, university of mohaghegh ardabili, ardabil, iran

شهربانو عریان |
department of biology, university of kharazmi, tehran, iran

علی نعمت اله زاده |
chemical engineering department, university of mohaghegh ardabili, ardabil, iran

معصومه دودل |
nanotechnology and tissue engineering department, stem cell technology research center, tehran, iran

مهدی اصغری vostakolaei | asghari vostakolaei
bone tissue engeneering, cell therapy research center, acecr ardabil branch

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_1459_448a2fe620c7150d5436d3508237fce1.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات