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Veterinary Research Forum، جلد ۷، شماره ۲، صفحات ۸۹-۹۷
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عنوان انگلیسی Anti-spermatogenic activities of Taraxacum officinale whole plant and leaves aqueous extracts
چکیده انگلیسی مقاله Taraxacum officinale has been used in Jordan folk medicine to treat male infertility. A recent study has proved a contradictory effect of the whole plant aqueous extract. The aim of the current study was to determine if the leaves of T. officinale have similar anti-fertility activities, and whether this effect is mediated through the regulation of spermatogonial stem cells (SSCs). Fifty adult male rats were divided into five groups. Two groups were gavaged with 1/10 of LD50 of T. officinale whole plant (1.06 g kg-1 body weight) or leaves (2.30 g kg-1 body weight) aqueous extract; while two groups were gavaged with 1/20 of LD50 of T. officinale whole plant (2.13 g kg-1) or leaves (4.60 g kg-1) extract. The control group received distilled water. Oral administration of T. officinale (whole plant and leaves aqueous extract) caused a significant decrease in testis and seminal vesicle weight, a reduction in serum testosterone concentration, impaired sperm parameters, and a decrease in pregnancy parameters. Testicular histology of treated rats showed structural changes such as hypoplasia of germ cells, reduction in the thickness of germinal epithelium, arrest of spermatogenesis at spermatid stage (late maturation arrest) and reduction in the number of Leydig cells. Gene expression levels of two SSCs markers (GFRα1 and CSF1) responsible for self-renewal were relatively counter-balanced. In conclusion, T. officinale whole plant and leaves aqueous extracts changed the gene expression of two SSCs markers leading to the imbalance between spermatogonia self-renewal and differentiation causing late maturation arrest.
کلیدواژه‌های انگلیسی مقاله Dandelion,Maturation arrest,Rat,Renewal,Spermatogenesis
نویسندگان مقاله lubna حمید tahtamouni | lubna hamid
department of biology and biotechnology, faculty of science, the hashemite university, zarqa, jordan

ریما احمد al khateeb | rema ahmad al khateeb
department of biology and biotechnology, faculty of science, the hashemite university, zarqa, jordan

reem ناصر abdellatif | reem nasser
department of biology and biotechnology, faculty of science, the hashemite university, zarqa, jordan

زینب علی al mazaydeh | zainab ali al mazaydeh
department of biology and biotechnology, faculty of science, the hashemite university, zarqa, jordan

سالم refaat یاسین | salem refaat
department of biology and biotechnology, faculty of science, the hashemite university, zarqa, jordan

سامر al gharabli | al gharabli
department of pharmaceutical and chemical engineering, school of applied medical sciences, german jordanian university, amman, jordan

علی زهیر elkarmi | ali zuhair
department of biology and biotechnology, faculty of science, the hashemite university, zarqa, jordan

نشانی اینترنتی http://vrf.iranjournals.ir/article_19920_efb5e6cc0a6cebd5eb55606e68f9273c.pdf
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