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Veterinary Research Forum، جلد ۷، شماره ۱، صفحات ۱-۶
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عنوان انگلیسی The effects of pomegranate extract on normal adult rat kidney: A stereological study
چکیده انگلیسی مقاله Pomegranate (Punica granatum L.) has been used widely in the traditional medicine of various civilizations for more than 5000 years. The pomegranate tree has several parts; each part has useful medicinal effects. Previous studies have demonstrated the antibacterial, antioxidant, and anti-inflammatory properties of pomegranate. The aim of the present study was to determine whether administration of pomegranate extract could result in morphometric changes in the kidneys of rats. Eighteen male rats (180-200 g) were divided into three groups that received either: G1, distilled water; G2, 250 mg kg-1 pomegranate extract; and G3, 500 mg kg-1 pomegranate extract via oral gavages daily for eight weeks. At the end of eight weeks, the rats were euthanized and their kidneys were removed and processed for morphometric analyses. In rats received pomegranate extract, the kidney weight, kidney weight/body weight ratio, cortex volume and glomerular volume were increased (p < 0.05), while, medulla volume and the number of glomeruli per kidney did not change. No pathological lesions were observed in the kidney. Therefore, pomegranate hydro-alcoholic extract at doses of 250 and 500 (mg kg-1) increased the volume of some parts of the kidney; however, it did not cause any pathological changes in the kidney.
کلیدواژه‌های انگلیسی مقاله Kidney,Pomegranate,Rat,Stereology
نویسندگان مقاله اسرافیل منصوری |
department of anatomical sciences, cellular and molecular research center, faculty of medicine, jundishapur university of medical sciences, ahvaz, iran

جان basgen |
life sciences institute, charles r. drew university of medicine and science, los angeles, usa

صادق صارمی |
department of anatomical sciences, cellular and molecular research center, faculty of medicine, jundishapur university of medical sciences, ahvaz, iran

نشانی اینترنتی http://vrf.iranjournals.ir/article_18999_b2a80f714d3b2c936efe01fa3bdb343b.pdf
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