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Iranian Heart Journal، جلد ۲۰، شماره ۲، صفحات ۳۲-۳۹
عنوان فارسی
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کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of the Effects of Prazosin on Resistant Diastolic Hypertension With a Focus on Sex Difference
چکیده انگلیسی مقاله Background: Despite all the focus on systolic blood pressure (SBP), few studies exist on high diastolic blood pressure (DBP) treatment between the different genders. In this study, we investigated the effects of prazosin as an additional treatment for refractory DBP. Methods: Totally, 75 nonblack adults were enrolled in this study with primary hypertension and DBP >100 mm Hg as isolated diastolic hypertension or systolic-diastolic hypertension. All the patients were treated with 1 or more drugs the 5 major antihypertensive group drugs (ACE-I, ARB, diuretic, Ca-channel blockers, and beta-blockers). If hypertension did not respond to these drugs, prazosin was added at a mean dose of 1–2 mg (1.6 mg) daily. Result: Many of the patients needed additional low doses of prazosin for the control of DBP. The response of the females was significantly better than that of the males to the 5 major antihypertensive drugs (P=0.001) . This study showed that the 5 major drug groups, albeit conferring good SBP control (25.8% reduction in SBP), in the majority of the patients only caused a 10% decrease in DBP. However, prazosin led to a 21.8% decrease in DBP and a 9.5% decrease in SBP. Consequently, prazosin could be an effective drug in controlling resistant DBP with minimal side effects. Conclusions: Low-dose prazosin as an additional drug to other major antihypertensive drugs with minor and transient complications can be reliably effective in reducing resistant DBP. 
کلیدواژه‌های انگلیسی مقاله Resistant, HTN-diastolic, HTN-systolic
نویسندگان مقاله Hakimeh Saadatifar |
Department of Echocardiography, Dezful University of Medical Sciences, Dezful, IR Iran

Fahimeh Khoshhal Dehdar |
Department of Echocardiography, Dezful University of Medical Sciences, Dezful, IR Iran

Maryam Moshkani Farahani |
Department of Echocardiography, Atherosclerosis Research Center, Baqiatallah University of Medical Sciences, Tehran, IR Iran

Mahmoud Salesi |
Chemical Injuries Research Center, Systems Biology and Poisons Institute, Baqiatallah University of Medical Sciences, Tehran, IR Iran

Samira Saadatifar |
Department of Echocardiography, Dezful University of Medical Sciences, Dezful, IR Iran

نشانی اینترنتی http://journal.iha.org.ir/article_85671_e864953eb633780debf1d43a4983b090.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/162/article-162-1423833.pdf
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