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Iranian Heart Journal، جلد ۲۰، شماره ۱، صفحات ۴۵-۵۲
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عنوان انگلیسی Effects of Spironolactone on Cardiovascular Complications in Hemodialysis Patients of Taleghani Hospital During the Period of 2016-2017: A Randomized Double-Blind Controlled Clinical Trial
چکیده انگلیسی مقاله Background: There is recent evidence that aldosterone plays a role in the pathogenesis ofcardiovascular diseases in dialysis patients, which leads to the opportunity to block its actionsfor the benefit of these patients. In non-dialytic chronic kidney diseases, spironolactone wassafe and effective in reducing left ventricular hypertrophy. However, its routine use has beenprecluded in hemodialysis patients due to the risk of hyperkalemia. The aim of the present studywas to verify the safety and efficacy of spironolactone in the regression of left ventricularhypertrophy and ejection fraction in hemodialysis patients undergoing pharmacotherapeuticmonitoring.Methods: We performed a controlled, randomized, double-blind study evaluating 48 hemodialysispatients divided into 2 groups. The first group received spironolactone at a dose of 25 mg afterhemodialysis over a few weeks, and the second group was the control. The patients werefollowed up for 9 months.Results: Both groups were composed of 24 patients each. The study groups did not differ in theirbaseline characteristics. The group receiving spironolactone had a significant improvement inthe left ventricular mass index and ejection fraction in comparison with the control group(P< 0.05).Conclusions: Spironolactone treatment in hemodialysis patients was safe and effective in regressingleft ventricular hypertrophy and improving the ejection fraction as major risk factors forcardiovascular events in these patients.
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نویسندگان مقاله Seyed Ahmad Reza Ziaee |
Department of Internal Medicine, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Mersedeh Karvandi |
Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Negar Sadat Ziaee |
Department of Internal Medicine, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Zohre Gholizadeh Ghozloujeh |
Clinical Research Development Unit (CRDU) of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Mohammad Amin Shahrbaf |
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Azamolsadat Roshan |
Department of Nephrology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

نشانی اینترنتی http://journal.iha.org.ir/article_82792_dafd20cddf1969fa5aa4e819dfba0637.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/162/article-162-1423846.pdf
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